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Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada
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These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(9), 16522-16543; https://doi.org/10.3390/ijms150916522
Received: 24 July 2014 / Revised: 21 August 2014 / Accepted: 11 September 2014 / Published: 18 September 2014
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics)
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. View Full-Text
Keywords: bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death bioactive lipids; lipid metabolism; lipidomics; bile acids; aging and age-related diseases; cancer; anti-aging and anti-tumor therapeutic agents; endoplasmic reticulum; mitochondria; cell death
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Arlia-Ciommo, A.; Piano, A.; Svistkova, V.; Mohtashami, S.; Titorenko, V.I. Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid. Int. J. Mol. Sci. 2014, 15, 16522-16543.

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