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Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?

Department of Biomedical Sciences and Department of Physiology, Korea University College of Medicine, Seoul 136-705, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(9), 16430-16457; https://doi.org/10.3390/ijms150916430
Received: 6 July 2014 / Revised: 15 August 2014 / Accepted: 28 August 2014 / Published: 17 September 2014
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics)
Oxidative stress induces numerous biological problems. Lipid oxidation and peroxidation appear to be important steps by which exposure to oxidative stress leads the body to a disease state. For its protection, the body has evolved to respond to and eliminate peroxidation products through the acquisition of binding proteins, reducing and conjugating enzymes, and excretion systems. During the past decade, researchers have identified a group of ion channel molecules that are activated by oxidized lipids: transient receptor potential (TRP) channels expressed in sensory neurons. These ion channels are fundamentally detectors and signal converters for body-damaging environments such as heat and cold temperatures, mechanical attacks, and potentially toxic substances. When messages initiated by TRP activation arrive at the brain, we perceive pain, which results in our preparing defensive responses. Excessive activation of the sensory neuronal TRP channels upon prolonged stimulations sometimes deteriorates the inflammatory state of damaged tissues by promoting neuropeptide release from expresser neurons. These same paradigms may also work for pathologic changes in the internal lipid environment upon exposure to oxidative stress. Here, we provide an overview of the role of TRP channels and oxidized lipid connections during abnormally increased oxidative signaling, and consider the sensory mechanism of TRP detection as an alert system. View Full-Text
Keywords: sensory TRP ion channels; pain; lipid peroxidation; oxidative stress sensory TRP ion channels; pain; lipid peroxidation; oxidative stress
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Choi, S.-I.; Yoo, S.; Lim, J.Y.; Hwang, S.W. Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation? Int. J. Mol. Sci. 2014, 15, 16430-16457.

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