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Int. J. Mol. Sci. 2014, 15(9), 16511-16521;

Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.

Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan
Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Epigenome Research Center, Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt
Department of Nursing, Meiho University, Pingtung 912, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 19 August 2014 / Revised: 11 September 2014 / Accepted: 12 September 2014 / Published: 18 September 2014
(This article belongs to the Section Biochemistry)
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The sponge Petrosia sp. yielded five polyacetylenic compounds (15), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 15 exhibited significant cytotoxic activity against a limited panel of cancer cell lines. View Full-Text
Keywords: sponge; Petrosia; polyacetylene sponge; Petrosia; polyacetylene

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Juan, Y.-S.; Lee, C.-C.; Tsao, C.-W.; Lu, M.-C.; El-Shazly, M.; Shih, H.-C.; Chen, Y.-C.; Wu, Y.-C.; Su, J.-H. Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.. Int. J. Mol. Sci. 2014, 15, 16511-16521.

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