Next Article in Journal
Silver Nanoparticles/Ibuprofen-Loaded Poly(l-lactide) Fibrous Membrane: Anti-Infection and Anti-Adhesion Effects
Next Article in Special Issue
MicroRNAs, Genomic Instability and Cancer
Previous Article in Journal
Mechanistic Understanding of Toxicity from Nanocatalysts
Previous Article in Special Issue
Non-Coding RNAs and Lipid Metabolism
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(8), 13993-14013;

Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria
Department of Surgery, St John of God Hospital Graz, Marschallgasse 12, A-8020 Graz, Austria
Division of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria
These authors have contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 23 July 2014 / Accepted: 5 August 2014 / Published: 12 August 2014
(This article belongs to the Collection Regulation by Non-Coding RNAs)
Full-Text   |   PDF [1096 KB, uploaded 12 August 2014]   |  


The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide. View Full-Text
Keywords: colorectal cancer; lncRNA; cancer; molecular tumor pathogenesis colorectal cancer; lncRNA; cancer; molecular tumor pathogenesis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Smolle, M.; Uranitsch, S.; Gerger, A.; Pichler, M.; Haybaeck, J. Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer. Int. J. Mol. Sci. 2014, 15, 13993-14013.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top