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Nanotoxicity Overview: Nano-Threat to Susceptible Populations

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
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Int. J. Mol. Sci. 2014, 15(3), 3671-3697; https://doi.org/10.3390/ijms15033671
Received: 10 January 2014 / Revised: 9 February 2014 / Accepted: 13 February 2014 / Published: 28 February 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications. View Full-Text
Keywords: nanotoxicity; susceptible populations; health risk; aged population; disease nanotoxicity; susceptible populations; health risk; aged population; disease
MDPI and ACS Style

Li, Y.; Zhang, Y.; Yan, B. Nanotoxicity Overview: Nano-Threat to Susceptible Populations. Int. J. Mol. Sci. 2014, 15, 3671-3697.

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