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Int. J. Mol. Sci. 2014, 15(11), 20789-20799;

Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis

Department of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Marine Campus of International Excellence (CEIMAR), Agrifood Campus of International Excellence (ceiA3), E-11510 Puerto Real, Spain
Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University of Madrid, E-28040 Madrid, Spain
IEO, Spanish Institute of Oceanography, Santander Oceanographic Centre, Promontorio de San Martín, s/n, P.O. Box 240, E-39080 Santander, Spain
Aragó Laboratory—UMR7628 (CNRS and UPMC) and GDR2821 (CNRS/Ifremer), F-66651 Banyuls/Mer, France
INMAR-CACYTMAR Research Institutes, Puerto Real University Campus, E-11510 Puerto Real, Spain
Present address: Department of Fish Physiology and Biotechnology, Institute of Aquaculture of Torre de la Sal, Spanish National Research Council (CSIC), Torre de la Sal, Ribera de Cabanes, E-12595 Castellón, Spain
Author to whom correspondence should be addressed.
Received: 29 July 2014 / Revised: 31 October 2014 / Accepted: 3 November 2014 / Published: 13 November 2014
(This article belongs to the Special Issue Advances in the Research of Melatonin 2014)
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Melatonin actions are mediated through G protein-coupled transmembrane receptors. Recently, mt1, mt2, and mel1c melatonin receptors were cloned in the Senegalese sole. Here, their day-night and developmental expressions were analyzed by quantitative PCR. These results revealed distinct expression patterns of each receptor through development. mel1c transcripts were more abundant in unfertilized ovulated oocytes and declined during embryonic development. mt1 and mt2 expression was higher at the earliest stages (2–6 days post-fertilization), decreasing before (mt2) or during (mt1) metamorphosis. Only mt1 and mel1c expression exhibited day-night variations, with higher nocturnal mRNA levels. These results suggest different roles and transcriptional regulation of these melatonin receptors during flatfish development and metamorphosis. View Full-Text
Keywords: melatonin receptors; development; metamorphosis; flatfish melatonin receptors; development; metamorphosis; flatfish

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Lan-Chow-Wing, O.; Confente, F.; Herrera-Pérez, P.; Isorna, E.; Chereguini, O.; Rendón, M.C.; Falcón, J.; Muñoz-Cueto, J.A. Distinct Expression Profiles of Three Melatonin Receptors during Early Development and Metamorphosis in the Flatfish Solea senegalensis. Int. J. Mol. Sci. 2014, 15, 20789-20799.

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