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CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast

Molecular Imaging Group, F. Medicine, University of Santiago Compostela, R/de San Francisco, s/n, Santiago de Compostela 15782, Spain
Nuclear Medicine Department, University Hospital Santiago Compostela (CHUS), R/Choupana, s/n, Santiago de Compostela 15706, Spain
Fundación Tejerina, C/José Abascal, 40, Madrid 28003, Spain
General Lab, H. Virgen Xunqueira, P/Pepe Sánchez, 7, Cee, A Coruña 15270, Spain
Anatomía Humana Area, University of Vigo, Lagoas-Marcosende, s/n, Vigo 36310, Spain
Surgery Department, Hospital of Monte Naranco, Av Fernández Vega, 107, Oviedo 33012, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(11), 19870-19876;
Received: 23 September 2014 / Revised: 20 October 2014 / Accepted: 23 October 2014 / Published: 31 October 2014
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
PDF [661 KB, uploaded 31 October 2014]


Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3 ± 4.2; range: 71–88; median 76). A group of 205 women with the same tumor but aged <70 years (62.8 ± 4.0; range: 55–70; median 63) was also considered for comparison. Tumor size, axillary lymph node involvement, distant metastasis and histological grade were taken account. Serum CA 15.3 was determined by luminescence assay. CA 15.3 serum concentrations ranged between 6 and 85 U/mL (median 22.9 U/mL), and were higher only in patients with greater (qualitative and quantitative; p: 0.041) tumor size. Our results show that in women with IDCs, and aged over 70 years, serum CA 15.3 serum concentrations are associated exclusively with a greater tumor size, being these findings different to those described in women with the same subtype of tumor considered as a whole or with lower age. View Full-Text
Keywords: breast cancer; ductal carcinoma; CA15.3; elderly breast cancer; ductal carcinoma; CA15.3; elderly
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ruibal, Á.; Aguiar, P.; Del Río, M.C.; Padín-Iruegas, M.E.; Arias, J.I.; Herranz, M. CA15.3 Serum Concentrations in Older Women with Infiltrating Ductal Carcinomas of the Breast. Int. J. Mol. Sci. 2014, 15, 19870-19876.

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