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Large Intervening Non-Coding RNA HOTAIR Is an Indicator of Poor Prognosis and a Therapeutic Target in Human Cancers

by Yanlan Yao 1, Jinming Li 2,*,† and Lunan Wang 2,*,†
1
National Center for Clinical Laboratories, Graduate School of Peking Union Medical College, Beijing Hospital of the Ministry of Health, No. 1 Dahua Road, Beijing 100083, China
2
National Center for Clinical Laboratories, Beijing Hospital of the Ministry of Health, No. 1 Dahua Road, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(10), 18985-18999; https://doi.org/10.3390/ijms151018985
Received: 25 June 2014 / Revised: 26 September 2014 / Accepted: 1 October 2014 / Published: 20 October 2014
(This article belongs to the Special Issue Advances in Molecular Oncology 2014)
In the human genome, the fraction of protein-coding genes that are stably transcribed is only up to 2%, with the remaining numerous RNAs having no protein-coding function. These non-coding RNAs (ncRNAs) have received considerable attention in cancer research in recent years. Breakthroughs have been made in understanding microRNAs and small interfering RNAs, but larger RNAs such as long ncRNAs (lncRNAs) remain an enigma. One lncRNA, HOX antisense intergenic RNA (HOTAIR), has been shown to be dysregulated in many types of cancer, including breast cancer, colorectal cancer, and hepatoma. HOTAIR functions as a regulatory molecule in a wide variety of biological processes. However, its mechanism of action has not been clearly elucidated. It is widely believed that HOTAIR mediates chromosomal remodeling and coordinates with polycomb repressive complex 2 (PRC2) to regulate gene expression. Further study of HOTAIR-related pathways and the role of HOTAIR in tumorigenesis and tumor progression may identify new treatment targets. In this review, we will focus on the characteristics of HOTAIR, as well as data pertaining to its mechanism and its association with cancers. View Full-Text
Keywords: HOTAIR; lncrna; polycomb repressive complex 2; prognosis; therapeutic target HOTAIR; lncrna; polycomb repressive complex 2; prognosis; therapeutic target
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Yao, Y.; Li, J.; Wang, L. Large Intervening Non-Coding RNA HOTAIR Is an Indicator of Poor Prognosis and a Therapeutic Target in Human Cancers. Int. J. Mol. Sci. 2014, 15, 18985-18999.

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