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Volume 13
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Review

The Role of Dicer in DNA Damage Repair

by
Kai-Fu Tang
* and
Hong Ren
*
Key Laboratory of Molecular Biology for Infectious Diseases of the State Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(12), 16769-16778; https://doi.org/10.3390/ijms131216769
Submission received: 29 September 2012 / Revised: 9 November 2012 / Accepted: 12 November 2012 / Published: 7 December 2012
Versions Notes

Abstract

Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-strand break sites were essential for DNA damage repair. Moreover, accumulating data have suggested that miroRNAs play pivotal roles in DNA damage repair. In this review, we discuss the molecular mechanisms by which loss of Dicer leads to DNA damage, as well as the role of Dicer in tumorigenesis.
Keywords: dicer; DNA damage; tumorigenesis dicer; DNA damage; tumorigenesis

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MDPI and ACS Style

Tang, K.-F.; Ren, H. The Role of Dicer in DNA Damage Repair. Int. J. Mol. Sci. 2012, 13, 16769-16778. https://doi.org/10.3390/ijms131216769

AMA Style

Tang K-F, Ren H. The Role of Dicer in DNA Damage Repair. International Journal of Molecular Sciences. 2012; 13(12):16769-16778. https://doi.org/10.3390/ijms131216769

Chicago/Turabian Style

Tang, Kai-Fu, and Hong Ren. 2012. "The Role of Dicer in DNA Damage Repair" International Journal of Molecular Sciences 13, no. 12: 16769-16778. https://doi.org/10.3390/ijms131216769

APA Style

Tang, K.-F., & Ren, H. (2012). The Role of Dicer in DNA Damage Repair. International Journal of Molecular Sciences, 13(12), 16769-16778. https://doi.org/10.3390/ijms131216769

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