Next Article in Journal
Microcystin-LR Induces Apoptosis via NF-κB /iNOS Pathway in INS-1 Cells
Next Article in Special Issue
Interplay of Dynamic Transcription and Chromatin Remodeling: Lessons from Yeast
Previous Article in Journal
Vma8p-GFP Fusions Can Be Functionally Incorporated into V-ATPase, Suggesting Structural Flexibility at the Top of V1
Review

Epigenetics: New Questions on the Response to Hypoxia

1
Instituto Leloir, Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina
2
Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires C1033AAJ, Argentina
3
Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(7), 4705-4721; https://doi.org/10.3390/ijms12074705
Received: 22 June 2011 / Revised: 8 July 2011 / Accepted: 8 July 2011 / Published: 21 July 2011
(This article belongs to the Special Issue Chromatin Assembly)
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. View Full-Text
Keywords: HIF; oxygen; stress; chromatin; histone; jumonji HIF; oxygen; stress; chromatin; histone; jumonji
Show Figures

MDPI and ACS Style

Perez-Perri, J.I.; Acevedo, J.M.; Wappner, P. Epigenetics: New Questions on the Response to Hypoxia. Int. J. Mol. Sci. 2011, 12, 4705-4721. https://doi.org/10.3390/ijms12074705

AMA Style

Perez-Perri JI, Acevedo JM, Wappner P. Epigenetics: New Questions on the Response to Hypoxia. International Journal of Molecular Sciences. 2011; 12(7):4705-4721. https://doi.org/10.3390/ijms12074705

Chicago/Turabian Style

Perez-Perri, Joel I., Julieta M. Acevedo, and Pablo Wappner. 2011. "Epigenetics: New Questions on the Response to Hypoxia" International Journal of Molecular Sciences 12, no. 7: 4705-4721. https://doi.org/10.3390/ijms12074705

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop