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Molecules 2003, 8(3), 297-309;

Immobilization of 1-[N-(M-Nitrobenzoyl)-α-D,L-Asparagyl]-2-Benzylbenzimidazole on Gellan

Department of Macromolecules, Faculty of Industrial Chemistry, “Gh.Asachi” Technical University of Iaşi, Bd. D. Mangeron, no 71 A, 6600 Iaşi, Romania
Department of Organic Chemistry “Al.I.Cuza” University of Iaşi, Bd. Carol, no 11, 6600 Iaşi, Romania
Author to whom correspondence should be addressed.
Received: 27 September 2002 / Revised: 8 March 2003 / Accepted: 10 March 2003 / Published: 31 March 2003
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This paper studies the dicyclohexylcarbodiimide activated coupling reaction through ester-type covalent bonds of an oxazolone derived from N-(m-nitrobenzoyl)-L-asparagic acid, ring opened with 2-benzylbenzimidazole, on gellan. Based on a centered, rotatory, composed, second order experimental design, the regression equation describing the dependence of the amount of drug chemically bonded to the support on the reaction parameters is obtained. The efficiency of the coupling reaction over the variation domain established is maximum when the parameters’ highest values are used. The kinetics of the drug’s release from the support are studied under alkaline hydrolysis conditions. View Full-Text
Keywords: Gellan; polymer-drug system; controlled release Gellan; polymer-drug system; controlled release

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Popa, M.; Şunel, V.; Rusu, L.B. Immobilization of 1-[N-(M-Nitrobenzoyl)-α-D,L-Asparagyl]-2-Benzylbenzimidazole on Gellan. Molecules 2003, 8, 297-309.

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