Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane

Huang, Shaoying; Huang, Yingjie; Jin, Jiaping; Gu, Haorui; Lin, Xufeng

doi:10.3390/molecules31030494

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Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane

by

Shaoying Huang

,

Yingjie Huang

,

Jiaping Jin

,

Haorui Gu

^*

and

Xufeng Lin

^*

Department of Chemistry, Zhejiang University, Hangzhou 310058, China

^*

Authors to whom correspondence should be addressed.

Molecules 2026, 31(3), 494; https://doi.org/10.3390/molecules31030494 (registering DOI)

Submission received: 21 December 2025 / Revised: 27 January 2026 / Accepted: 29 January 2026 / Published: 31 January 2026

(This article belongs to the Section Organic Chemistry)

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Abstract

Planar chiral bisphosphine ligands based on diphenyl [2.2]paracyclophane (PhPhanePHOS) were successfully synthesized in a practical manner in four steps from commercially available 4,12-bisbromo-[2.2]paracyclophane as a new family of bisphosphine ligands. The novel PhPhanePHOS ligands provide high catalytic activity in Pd-catalyzed asymmetric allylic alkylation reactions in preliminary experiments.

Keywords: planar; bisphosphine ligands; chiral; paracyclophane

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MDPI and ACS Style

Huang, S.; Huang, Y.; Jin, J.; Gu, H.; Lin, X. Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane. Molecules 2026, 31, 494. https://doi.org/10.3390/molecules31030494

AMA Style

Huang S, Huang Y, Jin J, Gu H, Lin X. Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane. Molecules. 2026; 31(3):494. https://doi.org/10.3390/molecules31030494

Chicago/Turabian Style

Huang, Shaoying, Yingjie Huang, Jiaping Jin, Haorui Gu, and Xufeng Lin. 2026. "Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane" Molecules 31, no. 3: 494. https://doi.org/10.3390/molecules31030494

APA Style

Huang, S., Huang, Y., Jin, J., Gu, H., & Lin, X. (2026). Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane. Molecules, 31(3), 494. https://doi.org/10.3390/molecules31030494

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Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane

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