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Article

Nephroprotective Effect of Black Panax vietnamensis var. fuscidiscus Against Cisplatin Toxicity

by
Huy-Truong Nguyen
1,
Thi My Duyen Ngo
2,
Mong Kha Tran
2,
Thi Kim Ngan Tran
2,
Truong Tuong Vy
2,
Thi Ngoc Giau Vo
2,
Le Viet Hoang
2,
Danh Duc Ong
2,
Yen Nhi Le Nguyen
2,
Kim Chi Thi Le
3 and
Kim Long Vu-Huynh
1,*
1
Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
2
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
3
Department for Facility Management, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
*
Author to whom correspondence should be addressed.
Molecules 2026, 31(10), 1586; https://doi.org/10.3390/molecules31101586
Submission received: 31 March 2026 / Revised: 6 May 2026 / Accepted: 6 May 2026 / Published: 9 May 2026
(This article belongs to the Special Issue Natural Bioactives and Functional Ingredients in Foods)
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Abstract

Panax vietnamensis var. fuscidiscus, or PVF, a member of Araliaceae, is a new and high-value variety of Vietnamese Ginseng (P. vietnamensis var. vietnamensis—VG). PVF shares some similarities in terms of its saponin profile with VG, including protopanaxadiol, protopanaxatriol, and ocotillol saponin. Previous research has revealed that the steaming process significantly increases the bioactivities of VG, especially the renal protective effect. In this study, PVF roots were steamed at a high temperature (120 °C) for 12 h to obtain Black PVF (BPVF). The BPVF extract was tested in both in vitro and in vivo models of cisplatin toxicity to assess its antioxidant and nephroprotective activities. The results showed that the BPVF obtained from the steaming process exhibited the highest antioxidant activity at 12 h. The chemical composition of BPVF is characterized by less-polar saponins such as G-Rg3, -Rg5, and ocotillol genin. The BPVF extract (200 mg/kg) reversed kidney injuries by significantly lowering serum creatinine and blood urea nitrogen (BUN) levels, which had increased due to cisplatin toxicity. The antioxidant effect of BPVF extract also prevented lipid peroxidation by lowering malondialdehyde (MDA) levels and restoring redox balance by increasing glutathione (GSH) content in kidney cells to nearly normal levels, with effects comparable to quercetin. This study provides evidence of BPVF’s therapeutic potential with respect to kidney injuries due to cisplatin toxicity.
Keywords: Panax vietnamensis var. fuscidiscus; cisplatin; nephrotoxicity; ocotillol saponin Panax vietnamensis var. fuscidiscus; cisplatin; nephrotoxicity; ocotillol saponin
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MDPI and ACS Style

Nguyen, H.-T.; Ngo, T.M.D.; Tran, M.K.; Tran, T.K.N.; Vy, T.T.; Vo, T.N.G.; Hoang, L.V.; Ong, D.D.; Le Nguyen, Y.N.; Le, K.C.T.; et al. Nephroprotective Effect of Black Panax vietnamensis var. fuscidiscus Against Cisplatin Toxicity. Molecules 2026, 31, 1586. https://doi.org/10.3390/molecules31101586

AMA Style

Nguyen H-T, Ngo TMD, Tran MK, Tran TKN, Vy TT, Vo TNG, Hoang LV, Ong DD, Le Nguyen YN, Le KCT, et al. Nephroprotective Effect of Black Panax vietnamensis var. fuscidiscus Against Cisplatin Toxicity. Molecules. 2026; 31(10):1586. https://doi.org/10.3390/molecules31101586

Chicago/Turabian Style

Nguyen, Huy-Truong, Thi My Duyen Ngo, Mong Kha Tran, Thi Kim Ngan Tran, Truong Tuong Vy, Thi Ngoc Giau Vo, Le Viet Hoang, Danh Duc Ong, Yen Nhi Le Nguyen, Kim Chi Thi Le, and et al. 2026. "Nephroprotective Effect of Black Panax vietnamensis var. fuscidiscus Against Cisplatin Toxicity" Molecules 31, no. 10: 1586. https://doi.org/10.3390/molecules31101586

APA Style

Nguyen, H.-T., Ngo, T. M. D., Tran, M. K., Tran, T. K. N., Vy, T. T., Vo, T. N. G., Hoang, L. V., Ong, D. D., Le Nguyen, Y. N., Le, K. C. T., & Vu-Huynh, K. L. (2026). Nephroprotective Effect of Black Panax vietnamensis var. fuscidiscus Against Cisplatin Toxicity. Molecules, 31(10), 1586. https://doi.org/10.3390/molecules31101586

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