Next Article in Journal
Preparation and Preclinical Evaluation of 18F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1)
Next Article in Special Issue
Structural Rearrangement in Cyclic Cu(II) Pyridyltriazole Complexes: Oxidation of Dabco to Oxalate and CO2 Conversion to Carbonate
Previous Article in Journal
Batch Preparation and Performance Study of Boehmite-Based Electrospun Nanofiber Separators for Lithium-Ion Batteries
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 29
Issue 16
10.3390/molecules29163937
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing

by
Xiaojin Yan
1,†,
Fan Yang
1,†,
Guanghao Lv
1,
Yuping Qiu
1,
Xiaoying Jia
1,
Qirong Hu
1,
Jia Zhang
2,
Jing Yang
2,
Xiangyuan Ouyang
1,
Lingyan Gao
1,* and
Chuandong Jia
1,*
1
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, China
2
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an 710069, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2024, 29(16), 3937; https://doi.org/10.3390/molecules29163937
Submission received: 30 July 2024 / Revised: 18 August 2024 / Accepted: 19 August 2024 / Published: 21 August 2024
(This article belongs to the Special Issue Host–Guest Inclusion Complexes and Their Miscellaneous Applications)
Browse Figures
Versions Notes

Abstract

Herein, we report a new strategy for the design of antibiotic agents based on the electrostatic interaction and hydrogen bonding, highlighting the significance of hydrogen bonding and the increased recognition sites in facilitating the interaction with bacterial cell membranes and DNA. A series of quaternary ammonium functionalized urea-based anion receptors were studied. While the monodentate mono-urea M1, bisurea M2, and trisurea M3 failed to break through the cell membrane barrier and thus could not kill bacteria, the extended bidentate dimers D1–D3 presented gradually increased membrane penetrating capabilities, DNA conformation perturbation abilities, and broad-spectrum antibacterial activities against E. coli, P. aeruginosa, S. aureus, E. faecalis, and S. epidermidis.
Keywords: supramolecular chemistry; hydrogen bonds; anion receptor; host–guest systems; DNA cleavage supramolecular chemistry; hydrogen bonds; anion receptor; host–guest systems; DNA cleavage
Graphical Abstract

Share and Cite

MDPI and ACS Style

Yan, X.; Yang, F.; Lv, G.; Qiu, Y.; Jia, X.; Hu, Q.; Zhang, J.; Yang, J.; Ouyang, X.; Gao, L.; et al. Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing. Molecules 2024, 29, 3937. https://doi.org/10.3390/molecules29163937

AMA Style

Yan X, Yang F, Lv G, Qiu Y, Jia X, Hu Q, Zhang J, Yang J, Ouyang X, Gao L, et al. Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing. Molecules. 2024; 29(16):3937. https://doi.org/10.3390/molecules29163937

Chicago/Turabian Style

Yan, Xiaojin, Fan Yang, Guanghao Lv, Yuping Qiu, Xiaoying Jia, Qirong Hu, Jia Zhang, Jing Yang, Xiangyuan Ouyang, Lingyan Gao, and et al. 2024. "Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing" Molecules 29, no. 16: 3937. https://doi.org/10.3390/molecules29163937

APA Style

Yan, X., Yang, F., Lv, G., Qiu, Y., Jia, X., Hu, Q., Zhang, J., Yang, J., Ouyang, X., Gao, L., & Jia, C. (2024). Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing. Molecules, 29(16), 3937. https://doi.org/10.3390/molecules29163937

Article Metrics

Back to TopTop