Preparation and Anti-Lung Cancer Activity Analysis of Guaiacyl-Type Dehydrogenation Polymer
Round 1
Reviewer 1 Report
Please provide a reference compound for comparison. It is important for readers to know the effectiveness of D3-5.
Are the activity of D3-5 are significant to inhibit A549 lung cancer cells ?
Any toxicity test e.g. on normal cell ?
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Zhou et al. described the synthesis of guaiacyl dehydrogenated lignin polymer (G-DHP) using coniferin as a substrate in the presence of β-glucosidase and laccase. The results indicate that the presence of an aldehyde group on the side chain of the phenylpropane unit of G-DHP enhances its anticancer activity. Although the topic is interesting, there are several issues that should be addressed.
- The result and presentation of figures 4 and 6 are very poor and not adequate for publication.
- A scale bar should be added to figures 3 and 5.
- The anticancer activity against normal cancer cell lines should be investigated.
- Further anticancer investigation should be addressed, such as the effect on migration and colony formation.
- There are many typos and grammar mistakes in the whole manuscript, which should be corrected and proofread.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
The authors have addressed most of my concerns; I recommend acceptance of this paper.
