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Article

The Hydrolytic Activity of Copper(II) Complexes with 1,4,7-Triazacyclononane Derivatives for the Hydrolysis of Phosphate Diesters

by
Michaela Buziková
,
Robert Willimetz
and
Jan Kotek
*
Department of Inorganic Chemistry, Charles University, Hlavova 2030, 128 40 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2023, 28(22), 7542; https://doi.org/10.3390/molecules28227542
Submission received: 17 October 2023 / Revised: 6 November 2023 / Accepted: 9 November 2023 / Published: 11 November 2023
(This article belongs to the Special Issue Structures and Applications of Transition Metal Complexes)
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Abstract

A set of substituted 1,4,7-triazacyclononane ligands was synthesised, including a wide series of novel derivatives bearing a thiazole or thiophene side group, with the potential to incorporate these derivatives into a polymeric material; some previously known/studied ligands were also synthesised for comparative purposes. The corresponding copper(II) complexes were prepared, and their ability to mediate the hydrolysis of phosphate ester bonds was studied via UV-Vis spectrophotometry, using bis(p-nitrophenyl)phosphate as a model substrate. Some of the prepared complexes showed a considerable enhancement of the phosphate ester hydrolysis in comparison with previously studied systems, which makes them some of the most effective complexes ever tested for this purpose. Therefore, these novel, potentially bifunctional systems could provide the possibility of creating new coating materials for medicinal devices that could prevent biofilm formation.
Keywords: artificial nuclease; coordination compound; bifunctional ligand artificial nuclease; coordination compound; bifunctional ligand

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MDPI and ACS Style

Buziková, M.; Willimetz, R.; Kotek, J. The Hydrolytic Activity of Copper(II) Complexes with 1,4,7-Triazacyclononane Derivatives for the Hydrolysis of Phosphate Diesters. Molecules 2023, 28, 7542. https://doi.org/10.3390/molecules28227542

AMA Style

Buziková M, Willimetz R, Kotek J. The Hydrolytic Activity of Copper(II) Complexes with 1,4,7-Triazacyclononane Derivatives for the Hydrolysis of Phosphate Diesters. Molecules. 2023; 28(22):7542. https://doi.org/10.3390/molecules28227542

Chicago/Turabian Style

Buziková, Michaela, Robert Willimetz, and Jan Kotek. 2023. "The Hydrolytic Activity of Copper(II) Complexes with 1,4,7-Triazacyclononane Derivatives for the Hydrolysis of Phosphate Diesters" Molecules 28, no. 22: 7542. https://doi.org/10.3390/molecules28227542

APA Style

Buziková, M., Willimetz, R., & Kotek, J. (2023). The Hydrolytic Activity of Copper(II) Complexes with 1,4,7-Triazacyclononane Derivatives for the Hydrolysis of Phosphate Diesters. Molecules, 28(22), 7542. https://doi.org/10.3390/molecules28227542

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