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Article

Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis

by
Helen M. Lindqvist
1,*,
Anna Winkvist
1,
Inger Gjertsson
2,
Philip C. Calder
3,4,*,
Aaron M. Armando
5,
Oswald Quehenberger
5,
Roxana Coras
6 and
Monica Guma
6
1
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
2
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
3
School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
4
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO16 6YD, UK
5
Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
6
Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
*
Authors to whom correspondence should be addressed.
Molecules 2023, 28(2), 717; https://doi.org/10.3390/molecules28020717
Submission received: 4 November 2022 / Revised: 4 January 2023 / Accepted: 10 January 2023 / Published: 11 January 2023
(This article belongs to the Special Issue Bioactive Lipids in Inflammatory Diseases)
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Abstract

Oxylipins derived from n-3 fatty acids are suggested as the link between these fatty acids and reduced inflammation. The aim of the present study was to explore the effect of a randomized controlled cross-over intervention on oxylipin patterns in erythrocytes. Twenty-three women with rheumatoid arthritis completed 2 × 11-weeks exchanging one cooked meal per day, 5 days a week, for a meal including 75 g blue mussels (source for n-3 fatty acids) or 75 g meat. Erythrocyte oxylipins were quantified by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The results were analyzed with multivariate data analysis. Orthogonal projections to latent structures (OPLS) with effect projections and with discriminant analysis were performed to compare the two diets’ effects on oxylipins. Wilcoxon signed rank test was used to test pre and post values for each dietary period as well as post blue-mussel vs. post meat. The blue-mussel diet led to significant changes in a few oxylipins from the precursor fatty acids arachidonic acid and dihomo-ɣ-linolenic acid. Despite significant changes in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and free EPA in erythrocytes in the mussel group, no concurrent changes in their oxylipins were seen. Further research is needed to study the link between n-3 fatty-acid intake, blood oxylipins, and inflammation.
Keywords: rheumatoid arthritis; seafood; n-3 LC PUFA; fatty acids; oxylipins; erythrocytes; eicosanoids rheumatoid arthritis; seafood; n-3 LC PUFA; fatty acids; oxylipins; erythrocytes; eicosanoids

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MDPI and ACS Style

Lindqvist, H.M.; Winkvist, A.; Gjertsson, I.; Calder, P.C.; Armando, A.M.; Quehenberger, O.; Coras, R.; Guma, M. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules 2023, 28, 717. https://doi.org/10.3390/molecules28020717

AMA Style

Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, Quehenberger O, Coras R, Guma M. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023; 28(2):717. https://doi.org/10.3390/molecules28020717

Chicago/Turabian Style

Lindqvist, Helen M., Anna Winkvist, Inger Gjertsson, Philip C. Calder, Aaron M. Armando, Oswald Quehenberger, Roxana Coras, and Monica Guma. 2023. "Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis" Molecules 28, no. 2: 717. https://doi.org/10.3390/molecules28020717

APA Style

Lindqvist, H. M., Winkvist, A., Gjertsson, I., Calder, P. C., Armando, A. M., Quehenberger, O., Coras, R., & Guma, M. (2023). Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules, 28(2), 717. https://doi.org/10.3390/molecules28020717

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