An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO2

Cui, Renle; Liu, Caihong; Zhang, Ping; Qin, Kun; Ge, Yanqing

doi:10.3390/molecules28020515

Open AccessArticle

An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂

by

Renle Cui

^†,

Caihong Liu

^†,

Ping Zhang

^†,

Kun Qin

^* and

Yanqing Ge

^*

Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Molecules 2023, 28(2), 515; https://doi.org/10.3390/molecules28020515

Submission received: 8 December 2022 / Revised: 25 December 2022 / Accepted: 29 December 2022 / Published: 5 January 2023

(This article belongs to the Special Issue Fluorescent Probes for Imaging and Diagnostics)

Download

Browse Figures

Review Reports Versions Notes

Abstract

A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO₂ in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO₂ in mitochondria and in vivo.

Keywords: ultra-large Stokes shifts; imidazo[1,2-a]pyridine; bioimaging; FRET; mitochondria

Share and Cite

MDPI and ACS Style

Cui, R.; Liu, C.; Zhang, P.; Qin, K.; Ge, Y. An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂. Molecules 2023, 28, 515. https://doi.org/10.3390/molecules28020515

AMA Style

Cui R, Liu C, Zhang P, Qin K, Ge Y. An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂. Molecules. 2023; 28(2):515. https://doi.org/10.3390/molecules28020515

Chicago/Turabian Style

Cui, Renle, Caihong Liu, Ping Zhang, Kun Qin, and Yanqing Ge. 2023. "An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂" Molecules 28, no. 2: 515. https://doi.org/10.3390/molecules28020515

APA Style

Cui, R., Liu, C., Zhang, P., Qin, K., & Ge, Y. (2023). An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂. Molecules, 28(2), 515. https://doi.org/10.3390/molecules28020515

Article Menu

An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO₂

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI