Neuroprotective Iridoids and Lignans from Valeriana amurensis
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural Elucidation
2.2. Detection of the Neuroprotective Effects
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Plant Materials
3.3. Extraction and Isolation
3.3.1. Xiecaoiridoidside A (1)
3.3.2. Xiecaoiridoidside B (2)
3.3.3. Xiecaoiridoidside C (3)
3.3.4. Xiecaoiridoidside D (4)
3.3.5. Xiecaoiridoidside E (5)
3.3.6. Xiecaolignanside A (6)
3.4. Monosaccharide Analysis of 1–6
3.5. Determination of the Cells’ Viability
3.6. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Position | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
1 | 4.26, d (11.8) 4.81, d (11.8) | 4.23, d (11.8) 4.79, d (11.8) | 6.40, brs | |||
2 | 7.11, brs | |||||
3 | 6.397, brs | 4.71, d (11.9) 4.75, d (11.9) | 4.67, d (11.7) 4.75, d (11.7) | |||
4 | 1.69, m 2.32, m | 1.69, m 2.32, m | ||||
5 | 1.48, m 1.96, m | 1.48, m 1.96, m | 3.09, brd (8.5) | 3.47, m | 3.49, m | 7.15, d (8.3) |
6 | 2.28, m | 2.28, m | 4.04, d (2.0) | 1.68, m 2.17, dd (13.2, 7.5) | 1.62, m 2.52, dd (13.6, 7.1) | 6.95, brd (7.6) |
7 | 2.94, d (4.5) | 2.89, d (4.5) | 3.37, d (2.2) | 4.41, t (3.7) | 4.38, t (3.7) | 5.01, s |
8 | 2.59, m | 2.56, m | ||||
9 | 1.21, d (6.5) | 1.20, d (6.5) | 2.05, m | 2.96, t (10.0) | 2.99, dd (9.1, 11.2) | 4.12, d (9.4) 3.99, d (9.4) |
10 | 1.47, s | 1.44, s | 3.69, d (3.2) | 4.15, dd (5.7, 9.6) 3.79, t (9.6) | 3.86, d (6.8) | |
11 | 4.21, d (11.6) 4.35, d (11.6) | 5.08, s 5.20, s | 5.08, s 5.19, s | |||
1′ | 4.33, d (7.8) | 4.43, d (7.7) | ||||
2′ | 7.42, d (8.3) | 7.62, d (8.3) | 2.18, d (6.7) | 3.20, t (8.5) | 3.18, t (8.5) | 7.25, d (8.3) |
3′ | 6.79, d (8.3) | 6.74, d (8.3) | 2.02, m | 3.37, m | 3.36, m | 6.78, d (8.4) |
4′ | 0.94, d (6.7) | 3.30, m | 3.29, m | |||
5′ | 6.79, d (8.3) | 6.74, d (8.3) | 0.94, d (6.7) | 3.28, m | 3.29, m | 6.78, d (8.4) |
6′ | 7.42, d (8.3) | 7.62, d (8.3) | 3.68, dd (4.6, 12.0) 3.86, brd (11.8) | 3.68, dd (3.6, 11.8) 3.86, brd (11.3) | 7.25, d (8.3) | |
7′ | 7.57, d (16.0) | 6.85, d (12.9) | 4.97, s | |||
8′ | 6.28, d (16.0) | 5.73, d (12.9) | ||||
9′ | 3.97, d (9.4) 4.10, d (9.4) | |||||
3-OCH3 | 3.88, s | |||||
1″ | 4.41, d (7.5) | 4.41, d (7.5) | 4.72, d (8.1) | 4.90, d (7.1) | ||
2″ | 3.20, t (8.0) | 3.20, t (8.0) | 3.35, m | 3.50, m | ||
3″ | 3.39, m | 3.39, m | 4.05, m | 3.40, m | ||
4″ | 3.32, m | 3.32, m | 3.48, dd (2.7, 9.3) | 3.41, m | ||
5″ | 3.30, m | 3.30, m | 3.68, m | 3.48, m | ||
6″ | 3.88, brd (11.6) 3.67, brd (11.9) | 3.88, brd (11.6) 3.67, brd (11.9) | 3.66, m 3.86, brd (9.8) | 3.70, brd (13.3) 3.87, m |
Position | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
1 | 68.7, CH2 | 68.3, CH2 | 90.8, CH | 177.2, C | 177.3, C | 133.4, C |
2 | 87.9, C | 87.7, C | 113.8, CH | |||
3 | 94.6, C | 94.7, C | 142.4, CH | 72.6, CH2 | 72.8, CH2 | 150.6, C |
4 | 31.7, CH2 | 31.7, CH2 | 109.8, C | 144.2, C | 144.1, C | 147.8, C |
5 | 34.4, CH2 | 34.4, CH2 | 35.4, CH | 40.9, CH | 41.1, CH | 117.7, CH |
6 | 39.5, CH | 39.4, CH | 59.9, CH | 41.1, CH2 | 40.2, CH2 | 121.6, CH |
7 | 61.6, CH | 61.3, CH | 60.3, CH | 72.9, CH | 83.7, CH | 88.9, CH |
8 | 179.8, C | 179.7, C | 80.2, C | 50.5, CH | 51.8, CH | 89.1, C |
9 | 22.0, CH3 | 22.0, CH3 | 43.6, CH | 45.2, CH | 45.1, CH | 76.8, CH2 |
10 | 18.0, CH3 | 18.1, CH3 | 67.2, CH2 | 69.6, CH2 | 61.7, CH2 | |
11 | 69.8, CH2 | 113.9, CH2 | 114.0, CH2 | |||
1′ | 127.2, C | 127.6, C | 173.2, C | 104.9, CH | 105.6, CH | 129.1, C |
2′ | 131.4, CH | 134.0, CH | 44.3, CH2 | 75.3, CH | 75.6, CH | 130.3, CH |
3′ | 117.1, CH | 116.12, CH | 27.0, CH | 78.3, CH | 78.3, CH | 115.9, CH |
4′ | 161.5, C | 160.3, C | 22.7, CH3 | 71.7, CH | 71.7, CH | 158.5, C |
5′ | 117.1, CH | 116.12, CH | 22.7, CH3 | 78.2, CH | 78.2, CH | 115.9, CH |
6′ | 131.4, CH | 134.0, CH | 62.8, CH2 | 62.8, CH2 | 130.3, CH | |
7′ | 147.2, CH | 146.1, CH | 89.1, CH | |||
8′ | 115.0, CH | 116.09, CH | 89.4, C | |||
9′ | 168.6, C | 167.6, C | 77.1, CH2 | |||
3-OCH3 | 56.9, CH3 | |||||
1″ | 98.2, CH | 98.2, CH | 100.4, CH | 103.1, CH | ||
2″ | 75.1, CH | 75.1, CH | 72.6, CH | 75.1, CH | ||
3″ | 78.1, CH | 78.1, CH | 73.2, CH | 78.3, CH | ||
4″ | 71.7, CH | 71.7, CH | 69.2, CH | 71.5, CH | ||
5″ | 78.2, CH | 78.2, CH | 75.6, CH | 78.0, CH | ||
6″ | 62.8, CH2 | 62.8, CH2 | 63.4, CH2 | 62.7, CH2 |
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Ye, M.; Lin, X.; Wang, Q.; Yang, B.; Wang, C. Neuroprotective Iridoids and Lignans from Valeriana amurensis. Molecules 2023, 28, 5793. https://doi.org/10.3390/molecules28155793
Ye M, Lin X, Wang Q, Yang B, Wang C. Neuroprotective Iridoids and Lignans from Valeriana amurensis. Molecules. 2023; 28(15):5793. https://doi.org/10.3390/molecules28155793
Chicago/Turabian StyleYe, Minhui, Xiaoju Lin, Qiuhong Wang, Bingyou Yang, and Changfu Wang. 2023. "Neuroprotective Iridoids and Lignans from Valeriana amurensis" Molecules 28, no. 15: 5793. https://doi.org/10.3390/molecules28155793