Next Article in Journal
The Improved DC Breakdown Strength Induced by Enhanced Interaction between SiO2 Nanoparticles and LLDPE Matrix
Next Article in Special Issue
A Study of the Chemical Composition, Antioxidant Potential, and Acute Toxicity of Bulgarian Tanacetum vulgare L. Essential Oil
Previous Article in Journal
A Compiled Update on Nutrition, Phytochemicals, Processing Effects, Analytical Testing and Health Effects of Chenopodium album: A Non-Conventional Edible Plant (NCEP)
Previous Article in Special Issue
Microscopic Droplet Size Analysis (MDSA) of “Five Thieves’ Oil” (Olejek Pięciu Złodziei) Essential Oil after the Nebulization Process
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 28
Issue 13
10.3390/molecules28134906
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil

by
Borislava Lechkova
1,
Diana Karcheva-Bahchevanska
1,
Kalin Ivanov
1,
Velislava Todorova
1,
Niko Benbassat
1,
Nadya Penkova
2,
Pepa Atanassova
2,
Lyudmil Peychev
3,
Petar Hrischev
4,
Zhivko Peychev
5,
Dimitar Terziev
6 and
Stanislava Ivanova
1,*
1
Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
2
Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
3
Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
4
Department of Physiology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
5
Department of Medical Informatics, Biostatistics and E-Learning, Faculty of Public Health, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
6
Second Department of Internal Diseases, Section of Gastroenterology, Faculty of Medicine, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria
*
Author to whom correspondence should be addressed.
Molecules 2023, 28(13), 4906; https://doi.org/10.3390/molecules28134906
Submission received: 5 May 2023 / Revised: 3 June 2023 / Accepted: 20 June 2023 / Published: 22 June 2023
(This article belongs to the Special Issue Essential Oils II)
Browse Figures
Versions Notes

Abstract

Background: Tanacetum parthenium (L.) Sch.Bip. (T. parthenium) is an aromatic perennial plant belonging to the Asteraceae family, also known as feverfew. It is widely distributed in various regions of Europe and other parts of the world. The plant has a rich background in the traditional medicine of many nations and has been used as a remedy for fever, pain, inflammation, asthma, rheumatism, menstrual disorders, etc. Methods: GC–MS analysis was conducted to determine the chemical composition of the isolated essential oil (EO). Using the method proposed by Litchfield and Wilcoxon, the average lethal dose (LD50) of the EO on Wistar rats was determined for two routes of administration: oral (p.o.) and intraperitoneal (i.p.). The subacute toxicity of the EO was also tested by oral administration of a daily dose of 1.0 g/kg body weight (BW) for 28 days. The toxicity of the EO was evaluated by observing and evaluating changes in behavior, body weight, basic hematological and serum biochemical parameters, and histopathological changes of the internal organs. Results: Thirty-seven volatile organic compounds representing 94.58% of the total oil composition were tentatively detected in the obtained T. parthenium EO. The dominant compounds were camphor (45.47%), trans-chrisantenyl acetate (21.65%), camphene (9.48%), and cis-isogeraniol (5.42%). The results showed that the EO was not toxic when administered in acute oral doses. The acute mean lethal dose for intraperitoneal administration was LD50 i.p. = 2.13 g/kg BW. In the subacute study involving administration of an oral dose of EO for 28 days, there were a number of changes in the hematological and serum biochemical parameters of the blood compared with the control group of animals. However, no symptoms of toxicity, changes in the body weight of the rats, death, or pathological changes in the histological indicators of the examined organs—brain, heart, stomach, liver, spleen and kidney—were found. Extrapolating the results obtained from the rat experiments, we can state that the EO is safe for use in doses below 1 g/kgBW for a period not exceeding one month.
Keywords: Tanacetum parthenium; essential oil; feverfew; acute and subacute toxicity; hematological; serum biochemical; histological parameters Tanacetum parthenium; essential oil; feverfew; acute and subacute toxicity; hematological; serum biochemical; histological parameters

Share and Cite

MDPI and ACS Style

Lechkova, B.; Karcheva-Bahchevanska, D.; Ivanov, K.; Todorova, V.; Benbassat, N.; Penkova, N.; Atanassova, P.; Peychev, L.; Hrischev, P.; Peychev, Z.; et al. A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil. Molecules 2023, 28, 4906. https://doi.org/10.3390/molecules28134906

AMA Style

Lechkova B, Karcheva-Bahchevanska D, Ivanov K, Todorova V, Benbassat N, Penkova N, Atanassova P, Peychev L, Hrischev P, Peychev Z, et al. A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil. Molecules. 2023; 28(13):4906. https://doi.org/10.3390/molecules28134906

Chicago/Turabian Style

Lechkova, Borislava, Diana Karcheva-Bahchevanska, Kalin Ivanov, Velislava Todorova, Niko Benbassat, Nadya Penkova, Pepa Atanassova, Lyudmil Peychev, Petar Hrischev, Zhivko Peychev, and et al. 2023. "A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil" Molecules 28, no. 13: 4906. https://doi.org/10.3390/molecules28134906

APA Style

Lechkova, B., Karcheva-Bahchevanska, D., Ivanov, K., Todorova, V., Benbassat, N., Penkova, N., Atanassova, P., Peychev, L., Hrischev, P., Peychev, Z., Terziev, D., & Ivanova, S. (2023). A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil. Molecules, 28(13), 4906. https://doi.org/10.3390/molecules28134906

Article Metrics

Back to TopTop