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Volume 27
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10.3390/molecules27248956
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Review

Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation

by
Lu Yang
1,2,3,
Hongwei Su
1,3,
Yue Sun
1,2,3,
Sen Zhang
1,2,3,
Maosheng Cheng
1,3,* and
Yongxiang Liu
1,2,3,*
1
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
2
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
3
Institute of Drug Research in Medicine Capital of China, Shenyang Pharmaceutical University, Benxi 117000, China
*
Authors to whom correspondence should be addressed.
Molecules 2022, 27(24), 8956; https://doi.org/10.3390/molecules27248956
Submission received: 29 November 2022 / Revised: 12 December 2022 / Accepted: 13 December 2022 / Published: 15 December 2022
(This article belongs to the Special Issue New Approaches to Synthetic Organic Chemistry)
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Abstract

Gold catalysts possess the advantages of water and oxygen resistance, with the possibility of catalyzing many novel chemical transformations, especially in the syntheses of small-molecule skeletons, in addition to achieving the rapid construction of multiple chemical bonds and ring systems in one step. In this feature paper, we summarize recent advances in the construction of small-molecule scaffolds, such as benzene, cyclopentene, furan, and pyran, based on gold-catalyzed cyclization of arylalkyne derivatives within the last decade. We hope that this review will serve as a useful reference for chemists to apply gold-catalyzed strategies to the syntheses of related natural products and active molecules, hopefully providing useful guidance for the exploration of additional novel gold-catalyzed approaches.
Keywords: gold(I)-catalyzed; arylalkyne; benzene derivatives; cyclopentene derivatives; furan and pyran derivatives gold(I)-catalyzed; arylalkyne; benzene derivatives; cyclopentene derivatives; furan and pyran derivatives
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MDPI and ACS Style

Yang, L.; Su, H.; Sun, Y.; Zhang, S.; Cheng, M.; Liu, Y. Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation. Molecules 2022, 27, 8956. https://doi.org/10.3390/molecules27248956

AMA Style

Yang L, Su H, Sun Y, Zhang S, Cheng M, Liu Y. Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation. Molecules. 2022; 27(24):8956. https://doi.org/10.3390/molecules27248956

Chicago/Turabian Style

Yang, Lu, Hongwei Su, Yue Sun, Sen Zhang, Maosheng Cheng, and Yongxiang Liu. 2022. "Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation" Molecules 27, no. 24: 8956. https://doi.org/10.3390/molecules27248956

APA Style

Yang, L., Su, H., Sun, Y., Zhang, S., Cheng, M., & Liu, Y. (2022). Recent Advances in Gold(I)-Catalyzed Approaches to Three-Type Small-Molecule Scaffolds via Arylalkyne Activation. Molecules, 27(24), 8956. https://doi.org/10.3390/molecules27248956

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