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Volume 27
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10.3390/molecules27238276
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Article

Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy

by
Sonia Pielorz
,
Magdalena Węglińska
,
Sylwester Mazurek
and
Roman Szostak
*
Department of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(23), 8276; https://doi.org/10.3390/molecules27238276
Submission received: 28 October 2022 / Revised: 22 November 2022 / Accepted: 24 November 2022 / Published: 27 November 2022
(This article belongs to the Section Analytical Chemistry)
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Abstract

Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66–92% (w/w) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0–2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5–100.5% range.
Keywords: diosmin; Raman; infrared; NIR; quantitative analysis; pharmaceutical preparations; PCA; PLS diosmin; Raman; infrared; NIR; quantitative analysis; pharmaceutical preparations; PCA; PLS

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MDPI and ACS Style

Pielorz, S.; Węglińska, M.; Mazurek, S.; Szostak, R. Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy. Molecules 2022, 27, 8276. https://doi.org/10.3390/molecules27238276

AMA Style

Pielorz S, Węglińska M, Mazurek S, Szostak R. Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy. Molecules. 2022; 27(23):8276. https://doi.org/10.3390/molecules27238276

Chicago/Turabian Style

Pielorz, Sonia, Magdalena Węglińska, Sylwester Mazurek, and Roman Szostak. 2022. "Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy" Molecules 27, no. 23: 8276. https://doi.org/10.3390/molecules27238276

APA Style

Pielorz, S., Węglińska, M., Mazurek, S., & Szostak, R. (2022). Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy. Molecules, 27(23), 8276. https://doi.org/10.3390/molecules27238276

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