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Article

Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii

by
Phan Thi Hoai Trinh
1,†,
Anton N. Yurchenko
2,*,†,
Olga O. Khmel
3,
Trang Vo Thi Dieu
1,
Ngo Thi Duy Ngoc
1,
Elena V. Girich
2,
Alexander S. Menshov
2,
Natalya Y. Kim
2,
Ekaterina A. Chingizova
2,
Tran Thi Thanh Van
1,
Jong Seok Lee
4,
Hyi-Seung Lee
4 and
Ekaterina A. Yurchenko
2,*
1
Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam
2
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, Vladivostok 690022, Russia
3
Institute of High Technologies and Advanced Materials, Far Eastern Federal University, 10 Ajax Bay, Russky Island, Vladivostok 690922, Russia
4
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2022, 27(21), 7650; https://doi.org/10.3390/molecules27217650
Submission received: 4 October 2022 / Revised: 1 November 2022 / Accepted: 3 November 2022 / Published: 7 November 2022
(This article belongs to the Special Issue Advances in Cytoprotective Drug Discovery II)
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Abstract

The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher’s method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.
Keywords: marine fungi; Lopadostoma pouzarii; sea sponge; secondary metabolites; polyketides; cytotoxicity; cardioprotection marine fungi; Lopadostoma pouzarii; sea sponge; secondary metabolites; polyketides; cytotoxicity; cardioprotection
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MDPI and ACS Style

Trinh, P.T.H.; Yurchenko, A.N.; Khmel, O.O.; Dieu, T.V.T.; Ngoc, N.T.D.; Girich, E.V.; Menshov, A.S.; Kim, N.Y.; Chingizova, E.A.; Van, T.T.T.; et al. Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii. Molecules 2022, 27, 7650. https://doi.org/10.3390/molecules27217650

AMA Style

Trinh PTH, Yurchenko AN, Khmel OO, Dieu TVT, Ngoc NTD, Girich EV, Menshov AS, Kim NY, Chingizova EA, Van TTT, et al. Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii. Molecules. 2022; 27(21):7650. https://doi.org/10.3390/molecules27217650

Chicago/Turabian Style

Trinh, Phan Thi Hoai, Anton N. Yurchenko, Olga O. Khmel, Trang Vo Thi Dieu, Ngo Thi Duy Ngoc, Elena V. Girich, Alexander S. Menshov, Natalya Y. Kim, Ekaterina A. Chingizova, Tran Thi Thanh Van, and et al. 2022. "Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii" Molecules 27, no. 21: 7650. https://doi.org/10.3390/molecules27217650

APA Style

Trinh, P. T. H., Yurchenko, A. N., Khmel, O. O., Dieu, T. V. T., Ngoc, N. T. D., Girich, E. V., Menshov, A. S., Kim, N. Y., Chingizova, E. A., Van, T. T. T., Lee, J. S., Lee, H.-S., & Yurchenko, E. A. (2022). Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii. Molecules, 27(21), 7650. https://doi.org/10.3390/molecules27217650

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