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Review

Stevia Genus: Phytochemistry and Biological Activities Update

by
Jimena Borgo
1,2,3,
Laura C. Laurella
1,2,
Florencia Martini
1,3,
Cesar A. N. Catalán
4 and
Valeria P. Sülsen
1,2,3,*
1
Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), CONICET—Universidad de Buenos Aires, Buenos Aires 1113, Argentina
2
Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina
3
Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113, Argentina
4
Instituto de Química Orgánica, Facultad de Bioquímica Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471 (T4000INI), San Miguel de Tucumán T4000, Argentina
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(9), 2733; https://doi.org/10.3390/molecules26092733
Submission received: 7 April 2021 / Revised: 28 April 2021 / Accepted: 30 April 2021 / Published: 6 May 2021
(This article belongs to the Special Issue Natural Products: From Isolation and Identification to Biological Activity—Second Edition)
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Abstract

The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to the Stevia genus are considered medicinal and have been popularly used to treat different ailments. The members from this genus produce sesquiterpene lactones, diterpenes, longipinanes, and flavonoids as the main types of phytochemicals. Many pharmacological activities have been described for Stevia extracts and isolated compounds, antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative activities being the most frequently mentioned. This review aims to present an update of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds.
Keywords: Stevia; sesquiterpene lactones; diterpenes; flavonoids; biological activity Stevia; sesquiterpene lactones; diterpenes; flavonoids; biological activity
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MDPI and ACS Style

Borgo, J.; Laurella, L.C.; Martini, F.; Catalán, C.A.N.; Sülsen, V.P. Stevia Genus: Phytochemistry and Biological Activities Update. Molecules 2021, 26, 2733. https://doi.org/10.3390/molecules26092733

AMA Style

Borgo J, Laurella LC, Martini F, Catalán CAN, Sülsen VP. Stevia Genus: Phytochemistry and Biological Activities Update. Molecules. 2021; 26(9):2733. https://doi.org/10.3390/molecules26092733

Chicago/Turabian Style

Borgo, Jimena, Laura C. Laurella, Florencia Martini, Cesar A. N. Catalán, and Valeria P. Sülsen. 2021. "Stevia Genus: Phytochemistry and Biological Activities Update" Molecules 26, no. 9: 2733. https://doi.org/10.3390/molecules26092733

APA Style

Borgo, J., Laurella, L. C., Martini, F., Catalán, C. A. N., & Sülsen, V. P. (2021). Stevia Genus: Phytochemistry and Biological Activities Update. Molecules, 26(9), 2733. https://doi.org/10.3390/molecules26092733

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