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Article

Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys

1
College of Life Sciences, Northwest A & F University, Yangling 712100, China
2
Institute of Landscape, Taiyuan University, Taiyuan 030032, China
3
Zhejiang Provincial Key Laboratory of Plant Secondary Metabolism Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Petruczynik
Molecules 2021, 26(9), 2417; https://doi.org/10.3390/molecules26092417
Received: 22 March 2021 / Revised: 16 April 2021 / Accepted: 19 April 2021 / Published: 21 April 2021
(This article belongs to the Special Issue Natural Products: Isolation, Identification and Biological Activity)
Proanthocyanidins are natural glycosidase inhibitors with excellent antioxidant activity. This study aims to search for a new source of proanthocyanidins for the prevention and treatment of type 2 diabetes with higher content and better activity and get their structure elucidated. First, the total proanthocyanidins contents (TOPCs), antioxidant activity, antidiabetic activity of seven common Polygonaceae plants were analyzed and compared. Then proanthocyanidins from the rhizome of Fagopyrum dibotrys were purified, and the detailed structure was comprehensively analyzed by ultraviolet visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), 13C nuclear magnetic resonance spectroscopy (13C NMR), reversed-phase high-performance liquid chromatography-electrospray mass spectrometry (RP-HPLC-ESI-MS), and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The rhizome of F. dibotrys showed the highest TOPCs, the strongest antioxidant, and antidiabetic activities; the TOPCs, antioxidant and antidiabetic activities were all very significantly positively correlated. Proanthocyanidins purified from the rhizome of F. dibotrys showed better antidiabetic activity than grape seed proanthocyanidins (GsPs). Seventy-two proanthocyanidins from trimer to undecamer with a mean degree of polymerization (mDP) of about 5.02 ± 0.21 were identified with catechin and epicatechin as the dominant monomers. Conclusion: Proanthocyanidins are the main antioxidant and antidiabetic active substances of F. dibotrys and are expected to be developed into potential antioxidant and hypoglycemic products. View Full-Text
Keywords: Fagopyrum dibotrys; proanthocyanidins; antioxidant; antidiabetes; structural analysis Fagopyrum dibotrys; proanthocyanidins; antioxidant; antidiabetes; structural analysis
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MDPI and ACS Style

Li, X.; Liu, J.; Chang, Q.; Zhou, Z.; Han, R.; Liang, Z. Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. Molecules 2021, 26, 2417. https://doi.org/10.3390/molecules26092417

AMA Style

Li X, Liu J, Chang Q, Zhou Z, Han R, Liang Z. Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys. Molecules. 2021; 26(9):2417. https://doi.org/10.3390/molecules26092417

Chicago/Turabian Style

Li, Xin, Jingling Liu, Qinxiang Chang, Ziyun Zhou, Ruilian Han, and Zongsuo Liang. 2021. "Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys" Molecules 26, no. 9: 2417. https://doi.org/10.3390/molecules26092417

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