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Review

Vegetable Extracts and Nutrients Useful in the Recovery from Helicobacter pylori Infection: A Systematic Review on Clinical Trials

1
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
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CEINGE-Biotecnologie Avanzate, 80131 Naples, Italy
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Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
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International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
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Department of Experimental, Diagnostic and Specially Medicine, University of Bologna, via San Giacomo 14, 40126 Bologna, Italy
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Laboratorio di Patologia delle Infezioni Associate all’Impianto, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Simone Carradori
Molecules 2021, 26(8), 2272; https://doi.org/10.3390/molecules26082272
Received: 30 March 2021 / Revised: 10 April 2021 / Accepted: 11 April 2021 / Published: 14 April 2021
Helicobacter pylori (H. pylori) infections affect almost half of the world’s population, with gradually increasing incidence in developed countries. Eradication of H. pylori may provide significant benefits to the affected individual by healing a number of gastrointestinal and extra-digestive disorders. But due to increased microbial resistance and lack of patient adherence to the therapy, the eradication rate of H. pylori is below 80% with current pharmacological therapies. The usage of botanicals for their therapeutic purposes and medicinal properties have been increased in last decades. They can be use as alternative H. pylori treatments, especially against drug-resistant strains. Epidemiological studies have revealed that people with lower vegetable and micronutrient intake may be at increased risk of H. pylori infection. We have undertaken a review of clinical trials to evaluate the efficacy of vegetable extracts and micronutrients in patients with H. pylori. Various databases, such as Google Scholar, PubMed, Scopus, Web of Science, and the Cochrane Library, were searched for the articles published in English. A total of 24 clinical studies (15 for vegetable extracts and 9 for micronutrients) were selected to be reviewed and summarized in this article. Vegetable extracts (Broccoli sprouts, curcumin, Burdock complex, and Nigella sativa) and micronutrients (vitamin C and E) were not found to be as effective as single agents in H. pylori eradication, rather their efficacy synergized with conventional pharmacological therapies. Conversely, GutGard was found to be significantly effective as a single agent when compared to placebo control. View Full-Text
Keywords: Helicobacter pylori; alternative therapies; vegetable extracts; micronutrients; clinical trials Helicobacter pylori; alternative therapies; vegetable extracts; micronutrients; clinical trials
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MDPI and ACS Style

Ullah, H.; Di Minno, A.; Santarcangelo, C.; Khan, H.; Xiao, J.; Arciola, C.R.; Daglia, M. Vegetable Extracts and Nutrients Useful in the Recovery from Helicobacter pylori Infection: A Systematic Review on Clinical Trials. Molecules 2021, 26, 2272. https://doi.org/10.3390/molecules26082272

AMA Style

Ullah H, Di Minno A, Santarcangelo C, Khan H, Xiao J, Arciola CR, Daglia M. Vegetable Extracts and Nutrients Useful in the Recovery from Helicobacter pylori Infection: A Systematic Review on Clinical Trials. Molecules. 2021; 26(8):2272. https://doi.org/10.3390/molecules26082272

Chicago/Turabian Style

Ullah, Hammad, Alessandro Di Minno, Cristina Santarcangelo, Haroon Khan, Jianbo Xiao, Carla Renata Arciola, and Maria Daglia. 2021. "Vegetable Extracts and Nutrients Useful in the Recovery from Helicobacter pylori Infection: A Systematic Review on Clinical Trials" Molecules 26, no. 8: 2272. https://doi.org/10.3390/molecules26082272

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