Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance
Abstract
:1. Introduction
2. Invention of Glyceryl Trinitrate
3. Dynamite
4. Biological Action of GTN
5. GTN as a Muscle Relaxant
6. The Coming of GTN
7. The GTN Conundrum
8. GTN Clearance versus Bioactivation
9. Non-Enzymatic Reactions
10. Mechanistic Evidence from Observations Outside of the Lab
11. Aldehyde Dehydrogenase (ALDH)
12. The Use of ALDH Inhibitors and ALDH Knockout Models
13. The Active Site of Mitochondrial Aldehyde Dehydrogenase
14. Nitrate Tolerance
15. GTN in Individuals with Lowered Alcohol Tolerance
16. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Pearson, R.; Butler, A. Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules 2021, 26, 6581. https://doi.org/10.3390/molecules26216581
Pearson R, Butler A. Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules. 2021; 26(21):6581. https://doi.org/10.3390/molecules26216581
Chicago/Turabian StylePearson, Russell, and Anthony Butler. 2021. "Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance" Molecules 26, no. 21: 6581. https://doi.org/10.3390/molecules26216581