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Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan
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Academic Editor: Pierangela Ciuffreda
Molecules 2021, 26(20), 6186; https://doi.org/10.3390/molecules26206186
Received: 24 September 2021 / Revised: 9 October 2021 / Accepted: 11 October 2021 / Published: 14 October 2021
(This article belongs to the Section Natural Products Chemistry)
Previously, the authors conducted phytochemical investigations of the aerial parts of Larrea tridentata and reported triterpene glycosides and lignan derivatives. In continuation of the preceding studies, 17 lignans and lignan glycosides (117) were isolated, including seven new compounds (17). Herein, the structure of the new compounds was determined based on spectroscopic analysis and enzymatic hydrolysis. The cytotoxicity of 117 against HL-60 human promyelocytic leukemia cells was examined. Compounds 411 and 1416 were cytotoxic to HL-60 cells, with IC50 values in the range of 2.7–17 μM. Compound 6, which was the most cytotoxic among the unprecedented compounds, was shown to induce apoptotic cell death in HL-60 cells. View Full-Text
Keywords: Larrea tridentata; Zygophyllaceae; aerial part; lignan; lignan glycoside; cytotoxicity; HL-60 cell; apoptosis; cell cycle Larrea tridentata; Zygophyllaceae; aerial part; lignan; lignan glycoside; cytotoxicity; HL-60 cell; apoptosis; cell cycle
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MDPI and ACS Style

Yokosuka, A.; Iguchi, T.; Jitsuno, M.; Mimaki, Y. Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata. Molecules 2021, 26, 6186. https://doi.org/10.3390/molecules26206186

AMA Style

Yokosuka A, Iguchi T, Jitsuno M, Mimaki Y. Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata. Molecules. 2021; 26(20):6186. https://doi.org/10.3390/molecules26206186

Chicago/Turabian Style

Yokosuka, Akihito, Tomoki Iguchi, Maki Jitsuno, and Yoshihiro Mimaki. 2021. "Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of Larrea tridentata" Molecules 26, no. 20: 6186. https://doi.org/10.3390/molecules26206186

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