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Review

Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component

1
The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China
2
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
3
The Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University, Lanzhou 730000, China
4
Gansu Key Laboratory of Reproductive Medicine and Embryology, The First Hospital of Lanzhou University, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Akihito Yokosuka
Molecules 2021, 26(19), 5949; https://doi.org/10.3390/molecules26195949
Received: 25 July 2021 / Revised: 1 September 2021 / Accepted: 3 September 2021 / Published: 30 September 2021
Ovarian cancer ranks seventh in the most common malignant tumors among female disease, which seriously threatens female reproductive health. It is characterized by hidden pathogenesis, missed diagnosis, high reoccurrence rate, and poor prognosis. In clinic, the first-line treatment prioritized debulking surgery with paclitaxel-based chemotherapy. The harsh truth is that female patients are prone to relapse due to the dissemination of tumor cells and drug resistance. In these circumstances, the development of new therapy strategies combined with traditional approaches is conductive to improving the quality of treatment. Among numerous drug resources, botanical compounds have unique advantages due to their potentials in multitarget functions, long application history, and wide availability. Previous studies have revealed the therapeutic effects of bioactive plant components in ovarian cancer. These natural ingredients act as part of the initial treatment or an auxiliary option for maintenance therapy, further reducing the tumor and metastatic burden. In this review, we summarized the functions and mechanisms of natural botanical components applied in human ovarian cancer. We focused on the molecular mechanisms of cell apoptosis, autophagy, RNA and DNA lesion, ROS damage, and the multiple-drug resistance. We aim to provide a theoretical reference for in-depth drug research so as to manage ovarian cancer better in clinic. View Full-Text
Keywords: ovarian cancer; natural plant products; molecular mechanisms; bioactive compounds; traditional Chinese medicine ovarian cancer; natural plant products; molecular mechanisms; bioactive compounds; traditional Chinese medicine
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MDPI and ACS Style

Wu, J.; Zhou, T.; Wang, Y.; Jiang, Y.; Wang, Y. Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component. Molecules 2021, 26, 5949. https://doi.org/10.3390/molecules26195949

AMA Style

Wu J, Zhou T, Wang Y, Jiang Y, Wang Y. Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component. Molecules. 2021; 26(19):5949. https://doi.org/10.3390/molecules26195949

Chicago/Turabian Style

Wu, Jingyuan, Tuoyu Zhou, Yinxue Wang, Yanbiao Jiang, and Yiqing Wang. 2021. "Mechanisms and Advances in Anti-Ovarian Cancer with Natural Plants Component" Molecules 26, no. 19: 5949. https://doi.org/10.3390/molecules26195949

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