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Review

Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskayast. 1, 153045 Ivanovo, Russia
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Academic Editors: Athina Geronikaki, Ana Margarida Gomes da Silva and Jean-Marc Sabatier
Molecules 2021, 26(17), 5292; https://doi.org/10.3390/molecules26175292
Received: 15 May 2021 / Revised: 4 August 2021 / Accepted: 18 August 2021 / Published: 31 August 2021
(This article belongs to the Special Issue Molecular Recognition of Host/Guest Molecules)
Molecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer—all these processes include the stage of structure recognition during complexation. The goal of this review is to solicit and publish the latest advances in the design and sensing and binding abilities of porphyrin-based heterotopic receptors with well-defined geometries, the recognition ability of which is realized due to ionic, H-bridge, charge transfer, hydrophobic, and hydrophilic interactions. The dissection of the considered low-energy processes at the molecular scale expands our capabilities in the development of effective systems for controlled recognition, selective delivery, and prolonged release of substrates of different natures (including drugs) to their sites of functioning. View Full-Text
Keywords: porphyrin; receptor; molecular recognition; host–guest interactions; binding cavities porphyrin; receptor; molecular recognition; host–guest interactions; binding cavities
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MDPI and ACS Style

Mamardashvili, G.; Mamardashvili, N.; Koifman, O. Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature. Molecules 2021, 26, 5292. https://doi.org/10.3390/molecules26175292

AMA Style

Mamardashvili G, Mamardashvili N, Koifman O. Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature. Molecules. 2021; 26(17):5292. https://doi.org/10.3390/molecules26175292

Chicago/Turabian Style

Mamardashvili, Galina, Nugzar Mamardashvili, and Oscar Koifman. 2021. "Macrocyclic Receptors for Identification and Selective Binding of Substrates of Different Nature" Molecules 26, no. 17: 5292. https://doi.org/10.3390/molecules26175292

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