Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural Determination
2.2. Cytotoxic and Antibacterial Activities
2.3. Acetylcholinesterase (AChE) Inhibitory Activities
2.4. Inhibition of Lipopolysaccharide (LPS)-Induced Nuclear Factor-κB (NF-κB)
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Fungal Material
3.3. Fermentation, Extraction and Isolation
(E)-2,4-Dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1)
3.4. Bioactivity Assay
3.5. Molecular Docking
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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No. | δC | δH (J in Hz) | HMBC | COSY |
---|---|---|---|---|
1 | 113.7 | |||
2 | 165.2 | |||
3 | 111.4 | |||
4 | 164.5 | |||
5 | 111.7 | 6.25 (CH, s) | C-1, C-1″, C-4 | |
6 | 139.5 | |||
7 | 194.8 | 9.80 (CH, s) | C-2, C-1, C-5 | |
1′ | 7.2 | 2.03 (CH3, s) | C-4, C-2, C-3 | |
1″ | 43.9 | 4.15 (CH2, s) | C-2″, C-6, C-1, C-5 | |
2″ | 198.9 | |||
3″ | 131.8 | 6.28 (CH, d, J = 14.6 Hz) | C-5″, 2″ | H-4″, H-5″ |
4″ | 146.3 | 7.09 (CH, m) | C-2″, C-5″ | H-5″, H-3″ |
5″ | 18.5 | 1.95 (CH3, d, J = 6.7 Hz) | C-4″, C-3″ | C-4″, C-3″ |
Compounds | Cytotoxic Activities | Antibacterial Activities | |
---|---|---|---|
A549 (IC50, μM) | MRSA (MIC, μM) | * Other Bacterial Strains | |
2 | / | 485.4 μM | / |
3 | 22.2 μM | / | / |
1, 4–8, 10–15 | / | / | / |
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Cai, J.; Chen, C.; Tan, Y.; Chen, W.; Luo, X.; Luo, L.; Yang, B.; Liu, Y.; Zhou, X. Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407. Molecules 2021, 26, 4851. https://doi.org/10.3390/molecules26164851
Cai J, Chen C, Tan Y, Chen W, Luo X, Luo L, Yang B, Liu Y, Zhou X. Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407. Molecules. 2021; 26(16):4851. https://doi.org/10.3390/molecules26164851
Chicago/Turabian StyleCai, Jian, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu, and Xuefeng Zhou. 2021. "Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407" Molecules 26, no. 16: 4851. https://doi.org/10.3390/molecules26164851