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Article

Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique

by
Aneta Ostróżka-Cieślik
1,*,
Barbara Dolińska
1,2 and
Florian Ryszka
2,†
1
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
2
“Biochefa” Pharmaceutical Research and Production Plant, Kasztanowa 3, 41-200 Sosnowiec, Poland
*
Author to whom correspondence should be addressed.
†
In the memory of Professor Florian Ryszka.
Molecules 2021, 26(11), 3465; https://doi.org/10.3390/molecules26113465
Submission received: 3 May 2021 / Revised: 4 June 2021 / Accepted: 5 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Bioactive Compounds and Antioxidant Activity of Extracts from Different Natural Plants)
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Abstract

Zinc is an effective anti-inflammatory and antioxidant trace element. The aim of this study was to analyse the protective effect of zinc and zinc–prolactin systems as additives of preservation solutions in the prevention of nephron damage caused during ischemia. The study used a model for storing isolated porcine kidneys in Biolasol®. The solution was modified with the addition of Zn at a dose of 1 µg/L and Zn: 1 µg/L with prolactin (PRL): 0.1 µg/L. After 2 h and 48 h of storage, the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, sodium, potassium, creatinine and total protein were determined. Zinc added to the Biolasol® composition at a dose of 1 µg/L showed minor effectiveness in the protection of nephrons. In turn, Zn2+ added to Biolasol + PRL (PRL: 0.1 µg/L) acted as a prolactin inhibitor. We do not recommend the addition of Zn(II) (1 µg/L) and Zn(II) (1 µg/L) + PRL (0.1 µg/L) to the Biolasol solution.
Keywords: zinc; prolactin; Biolasol; perfusion; preservation; renal zinc; prolactin; Biolasol; perfusion; preservation; renal

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MDPI and ACS Style

Ostróżka-Cieślik, A.; Dolińska, B.; Ryszka, F. Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique. Molecules 2021, 26, 3465. https://doi.org/10.3390/molecules26113465

AMA Style

Ostróżka-Cieślik A, Dolińska B, Ryszka F. Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique. Molecules. 2021; 26(11):3465. https://doi.org/10.3390/molecules26113465

Chicago/Turabian Style

Ostróżka-Cieślik, Aneta, Barbara Dolińska, and Florian Ryszka. 2021. "Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique" Molecules 26, no. 11: 3465. https://doi.org/10.3390/molecules26113465

APA Style

Ostróżka-Cieślik, A., Dolińska, B., & Ryszka, F. (2021). Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc–Prolactin Modified Preservation Solution Using a Static Cold Storage Technique. Molecules, 26(11), 3465. https://doi.org/10.3390/molecules26113465

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