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Review

Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis

1
Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
2
Division of Gastroenterology and Hepatology, Weill Cornell Medicine, 1293 York Avenue, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ivana Vucenik
Molecules 2021, 26(1), 31; https://doi.org/10.3390/molecules26010031
Received: 28 November 2020 / Revised: 18 December 2020 / Accepted: 20 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Bioactivity of Inositol Phosphates)
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Importantly, patients with IBD have a significantly increased risk for the development of colorectal carcinoma. Dietary inositol and its phosphates, as well as phospholipid derivatives, are well known to benefit human health in diverse pathologies including cancer prevention. Inositol phosphates including InsP3, InsP6, and other pyrophosphates, play important roles in cellular metabolic and signal transduction pathways involved in the control of cell proliferation, differentiation, RNA export, DNA repair, energy transduction, ATP regeneration, and numerous others. In the review, we highlight the biologic function and health effects of inositol and its phosphates including the nature and sources of these molecules, potential nutritional deficiencies, their biologic metabolism and function, and finally, their role in the prevention of colitis-induced carcinogenesis. View Full-Text
Keywords: inositol; inositol phosphates; colitis; carcinogenesis; chemoprevention inositol; inositol phosphates; colitis; carcinogenesis; chemoprevention
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MDPI and ACS Style

Weinberg, S.E.; Sun, L.Y.; Yang, A.L.; Liao, J.; Yang, G.Y. Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis. Molecules 2021, 26, 31. https://doi.org/10.3390/molecules26010031

AMA Style

Weinberg SE, Sun LY, Yang AL, Liao J, Yang GY. Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis. Molecules. 2021; 26(1):31. https://doi.org/10.3390/molecules26010031

Chicago/Turabian Style

Weinberg, Samuel E., Le Y. Sun, Allison L. Yang, Jie Liao, and Guang Y. Yang 2021. "Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis" Molecules 26, no. 1: 31. https://doi.org/10.3390/molecules26010031

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