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Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes

Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland
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Academic Editor: Masahide Hamaguchi
Molecules 2020, 25(9), 2224; https://doi.org/10.3390/molecules25092224
Received: 31 March 2020 / Revised: 28 April 2020 / Accepted: 2 May 2020 / Published: 9 May 2020
(This article belongs to the Special Issue Type 2 Diabetes-II: Pathogenesis, Diagnosis, and Treatment)
One of the concepts explaining the coincidence of obesity and type 2 diabetes (T2D) is the metaflammation theory. This chronic, low-grade inflammatory state originating from metabolic cells in response to excess nutrients, contributes to the development of T2D by increasing insulin resistance in peripheral tissues (mainly in the liver, muscles, and adipose tissue) and by targeting pancreatic islets and in this way impairing insulin secretion. Given the role of this not related to infection inflammation in the development of both: insulin resistance and insulitis, anti-inflammatory strategies could be helpful not only to control T2D symptoms but also to treat its causes. This review presents current concepts regarding the role of metaflammation in the development of T2D in obese individuals as well as data concerning possible application of different anti-inflammatory strategies (including lifestyle interventions, the extra-glycemic potential of classical antidiabetic compounds, nonsteroidal anti-inflammatory drugs, immunomodulatory therapies, and bariatric surgery) in the management of T2D. View Full-Text
Keywords: metaflammation; insulin resistance; insulitis; type 2 diabetes; anti-inflammatory treatment metaflammation; insulin resistance; insulitis; type 2 diabetes; anti-inflammatory treatment
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MDPI and ACS Style

Kuryłowicz, A.; Koźniewski, K. Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes. Molecules 2020, 25, 2224. https://doi.org/10.3390/molecules25092224

AMA Style

Kuryłowicz A, Koźniewski K. Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes. Molecules. 2020; 25(9):2224. https://doi.org/10.3390/molecules25092224

Chicago/Turabian Style

Kuryłowicz, Alina, and Krzysztof Koźniewski. 2020. "Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes" Molecules 25, no. 9: 2224. https://doi.org/10.3390/molecules25092224

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