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Iron-Catalyzed C–H Functionalizations under Triazole-Assistance

Laboratoire de Chemie Moléculaire (UMR CNRS 7509), Université de Strasbourg, ECPM 25 Rue Becquerel, 67087 Strasbourg, France
Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, Parco Area delle Scienze 17/A, I-43124 Parma, Italy
Author to whom correspondence should be addressed.
Academic Editor: Fabio Marchetti
Molecules 2020, 25(8), 1806;
Received: 30 March 2020 / Revised: 10 April 2020 / Accepted: 11 April 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Recent Advances in the Chemistry of Organoiron Compounds)
3d transition metals-catalyzed C–H bond functionalizations represent nowadays an important tool in organic synthesis, appearing as the most promising alternative to cross-coupling reactions. Among 3d transition metals, iron found widespread application due to its availability and benign nature, and it was established as an efficient catalyst in organic synthesis. In this context, the use of ortho-orientating directing groups (DGs) turned out to be necessary for promoting selective iron-catalyzed C–H functionalization reactions. Very recently, triazoles DGs were demonstrated to be more than an excellent alternative to the commonly employed 8-aminoquinoline (AQ) DG, as a result of their modular synthesis as well as the mild reaction conditions applied for their removal. In addition, their tunable geometry and electronics allowed for new unprecedented reactivities in iron-catalyzed C–H activation methodologies that will be summarized within this review. View Full-Text
Keywords: C‒H activation; iron; 1,2,3-triazole; catalysis C‒H activation; iron; 1,2,3-triazole; catalysis
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MDPI and ACS Style

Lanzi, M.; Cera, G. Iron-Catalyzed C–H Functionalizations under Triazole-Assistance. Molecules 2020, 25, 1806.

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