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Open AccessFeature PaperArticle

New Chlorinated 2,5-Diketopiperazines from Marine-Derived Bacteria Isolated from Sediments of the Eastern Mediterranean Sea

Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
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Academic Editor: Valeria Costantino
Molecules 2020, 25(7), 1509; https://doi.org/10.3390/molecules25071509
Received: 9 March 2020 / Revised: 21 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Sea-Inspired Molecules)
From the organic extracts of five bacterial strains isolated from marine sediments collected in the East Mediterranean Sea, three new (15, 16, 31) and twenty-nine previously reported (114, 1730, 32) metabolites bearing the 2,5-diketopiperazine skeleton were isolated. The structures of the chlorinated compounds 15, 16, and 31 were elucidated by extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 15 and 16 were evaluated for their antifungal activity against Candida albicans and Aspergillus niger but were proven inactive. The relevant literature is supplemented with complete NMR assignments and revisions for the 29 previously reported compounds. View Full-Text
Keywords: 2,5-diketopiperazine; marine bacteria; sediment; natural products; structure elucidation; antifungal activity evaluation 2,5-diketopiperazine; marine bacteria; sediment; natural products; structure elucidation; antifungal activity evaluation
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Harizani, M.; Katsini, E.; Georgantea, P.; Roussis, V.; Ioannou, E. New Chlorinated 2,5-Diketopiperazines from Marine-Derived Bacteria Isolated from Sediments of the Eastern Mediterranean Sea. Molecules 2020, 25, 1509.

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