Next Article in Journal
Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 Inhibitors
Previous Article in Journal
Band-Gap Energies of Choline Chloride and Triphenylmethylphosphoniumbromide-Based Systems
Open AccessArticle

Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine

1
Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou 310058, China
2
Department of Social Medicine, School of Medicine, Zhejiang University, Hangzhou 310058, China
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(7), 1496; https://doi.org/10.3390/molecules25071496
Received: 6 March 2020 / Revised: 22 March 2020 / Accepted: 25 March 2020 / Published: 25 March 2020
(This article belongs to the Section Bioorganic Chemistry)
Lactoferrin (Lf) is a conserved iron-binding glycoprotein with antimicrobial activity, which is present in secretions that recover mucosal sites regarded as portals of invaded pathogens. Although numerous studies have focused on exogenous Lf, little is known about its expression of endogenous Lf upon bacterial infection. In this study, we investigated the distribution of Lf in mice intestine during Escherichia coli (E. coli) K88 infection. PCR and immunohistology staining showed that mRNA levels of Lf significantly increased in duodenum, ileum and colon, but extremely decreased in jejunum at 8 h and 24 h after infection. Meanwhile, endogenous Lf was mostly located in the lamina propria of intestine villi, while Lf receptor (LfR) was in the crypts. It suggested that endogenous Lf-LfR interaction might not be implicated in the antibacterial process. In addition, it was interesting to find that the infiltration of neutrophils into intestine tissues was changed similarly to Lf expression. It indicated that the variations of Lf expression were rather due to an equilibrium between the recruitment of neutrophils and degranulation of activated neutrophils. Thus, this new knowledge will pave the way to a more effective understanding of the role of Lf in intestinal mucosal immunity. View Full-Text
Keywords: Lactoferrin; intestine; antibacterial; inflammatory response; neutrophil Lactoferrin; intestine; antibacterial; inflammatory response; neutrophil
Show Figures

Figure 1

MDPI and ACS Style

Liang, L.; Wang, Z.-J.; Ye, G.; Tang, X.-Y.; Zhang, Y.-Y.; Kong, J.-X.; Du, H.-H. Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine. Molecules 2020, 25, 1496.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop