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Open AccessArticle

Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model

Natural Sciences School, Pharmaceutical Sciences Department, Universidad Icesi, 760031 Cali, Colombia
School of Chemistry, Industrial University of Santander, 680003 Bucaramanga, Santander, Colombia
University of Würzburg, Institute for Pharmacy and Food Chemistry, 97074 Würzburg, Germany
Grupo Inmunomodulación, School of Medicine, Universidad de Antioquia, 050010 Medellín, Antioquia, Colombia
Department of Physiology and Biochemistry, School of Medicine, Universidad de Antioquia, Carrera 51D Nº 62–29, 050010 Medellin, Colombia
GENMOL Group. Sede de Investigación Universitaria, Universidad de Antioquia, Calle 62 # 52–59, 050010 Medellín, Colombia
Authors to whom correspondence should be addressed.
Molecules 2020, 25(7), 1486; (registering DOI)
Received: 25 February 2020 / Revised: 11 March 2020 / Accepted: 16 March 2020 / Published: 25 March 2020
(This article belongs to the Special Issue Bioactive Natural Compounds and Their Mechanisms of Action)
Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid are one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported. View Full-Text
Keywords: Cecropia telenitida; serjanic acid; type 2 diabetes Cecropia telenitida; serjanic acid; type 2 diabetes
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MDPI and ACS Style

Gutiérrez, G.; Giraldo-Dávila, D.; Combariza, M.Y.; Holzgrabe, U.; Tabares-Guevara, J.H.; Ramírez-Pineda, J.R.; Acín, S.; Muñoz, D.L.; Montoya, G.; Balcazar, N. Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model. Molecules 2020, 25, 1486.

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