Next Article in Journal
A Cyclodextrin-Based Controlled Release System in the Simulation of In Vitro Small Intestine
Next Article in Special Issue
Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
Previous Article in Journal
Blue Emitting Star-Shaped and Octasilsesquioxane-Based Polyanions Bearing Boron Clusters. Photophysical and Thermal Properties
Open AccessReview

Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

M.V. Lomonosov Moscow State University, Leninskie gory, 1-3, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Molecules 2020, 25(5), 1211;
Received: 15 February 2020 / Revised: 29 February 2020 / Accepted: 6 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue Small Molecules Targeting Protein-Protein Interactions)
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics. View Full-Text
Keywords: p53–MDM2 inhibitors; anticancer drugs; cytotoxicity p53–MDM2 inhibitors; anticancer drugs; cytotoxicity
Show Figures

Graphical abstract

MDPI and ACS Style

Beloglazkina, A.; Zyk, N.; Majouga, A.; Beloglazkina, E. Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction. Molecules 2020, 25, 1211.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop