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Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction

M.V. Lomonosov Moscow State University, Leninskie gory, 1-3, 119991 Moscow, Russia
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Molecules 2020, 25(5), 1211; https://doi.org/10.3390/molecules25051211
Received: 15 February 2020 / Revised: 29 February 2020 / Accepted: 6 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue Small Molecules Targeting Protein-Protein Interactions)
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics. View Full-Text
Keywords: p53–MDM2 inhibitors; anticancer drugs; cytotoxicity p53–MDM2 inhibitors; anticancer drugs; cytotoxicity
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Beloglazkina, A.; Zyk, N.; Majouga, A.; Beloglazkina, E. Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction. Molecules 2020, 25, 1211.

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