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Article

Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities

1
Chemical and Environmental Engineering Department, University of the Basque Country (UPV/EHU), Plaza Europa, 1, 20018 Donostia-San Sebastián, Spain
2
Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute-Donostia University Hospital, University of the Basque Country (UPV/EHU), 20014 Donostia-San Sebastián, Spain
3
Centre for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, 28029 Madrid, Spain
4
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(5), 1131; https://doi.org/10.3390/molecules25051131
Submission received: 28 January 2020 / Revised: 25 February 2020 / Accepted: 28 February 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Lignin – A Natural Resource with Huge Potential)

Abstract

The growing concern about the environmental impact and human health risk related to the excessive use of synthetic ingredients in cosmetics and topical formulations calls for the exploration of safe and sustainable natural alternatives. Lignin-rich lignocellulosic industrial wastes such as hazelnut and walnut shells were used as a lignin polymer source. Agro-derived lignins were evaluated as a potential natural active ingredient for health care products. Aside from the structural characteristics of isolated lignins, which were identified by GPC, Py-GC–MS, and 2D HSQC NMR techniques, functional properties such as antioxidant power and UV absorption ability were investigated. The SPF values found for creams containing 5% of hazelnut and walnut lignin content were 6.9 and 4.5, respectively. Additionally, both lignin types presented appropriate protection against UVA radiation, highly interesting property to block the full ultraviolet spectrum. The biological activity of isolated lignins assessed at different concentrations (0.01–1 mg/mL) and different times (24, 48, and 72 h) on murine fibroblast cell line 3T3 suggested their suitability for cosmetic applications.
Keywords: hazelnut lignin; walnut lignin; monomeric composition; UV protection; antioxidant; cytotoxicity hazelnut lignin; walnut lignin; monomeric composition; UV protection; antioxidant; cytotoxicity

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MDPI and ACS Style

Gordobil, O.; Olaizola, P.; Banales, J.M.; Labidi, J. Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities. Molecules 2020, 25, 1131. https://doi.org/10.3390/molecules25051131

AMA Style

Gordobil O, Olaizola P, Banales JM, Labidi J. Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities. Molecules. 2020; 25(5):1131. https://doi.org/10.3390/molecules25051131

Chicago/Turabian Style

Gordobil, Oihana, Paula Olaizola, Jesus M. Banales, and Jalel Labidi. 2020. "Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities" Molecules 25, no. 5: 1131. https://doi.org/10.3390/molecules25051131

APA Style

Gordobil, O., Olaizola, P., Banales, J. M., & Labidi, J. (2020). Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities. Molecules, 25(5), 1131. https://doi.org/10.3390/molecules25051131

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