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Open AccessArticle

Laboratory-Scale Preparation and Characterization of Dried Extract of Muirapuama (Ptychopetalum olacoides Benth) by Green Analytical Techniques

1
Post-Graduate Program in Pharmaceutical Sciences—PPGCF, Federal University of Amapá—UNIFAP, Rod. Juscelino Kubitschek, Km2, Macapá-AP 68903-419, Brazil
2
Organic Chemistry and Biochemistry Laboratory, State University of Amapá, UEAP, Avenida Presidente Vargas, 650, Macapá-AP 68900-070, Brazil
3
Drug Quality Control and Bromatology Laboratory—LCqB, Federal University of Amapá—UNIFAP, Rod. JuscelinoKubitschek, Km2, Macapá-AP 68903-419, Brazil
4
Research Group on Food and Medicines—NUPLAM, Federal University of Rio Grande do Norte—UFRN, Natal-RN 59072-970, Brazil
5
Drug Quality Control Laboratory, Pharmaceutical Sciences Department, Federal University of Rio Grande do Norte-UFRN, Av. General Cordeiro de Farias s/n, Natal-RN 59012-570, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Mihkel Koel and Marek Tobiszewski
Molecules 2020, 25(5), 1095; https://doi.org/10.3390/molecules25051095
Received: 22 January 2020 / Revised: 24 February 2020 / Accepted: 25 February 2020 / Published: 29 February 2020
This work reports on the preparation of a drying process from the ethanolic extract of Muirapuama and its characterization through green analytical techniques. The spray-drying processes were performed by using ethanolic extract in a ratio of 1:1 extract/excipient and 32 factorial design. The properties of dried powder were investigated in terms of total flavonoid content, moisture content, powder yield, and particle size distribution. An analytical eco-scale was applied to assess the greenness of the developed protocol. Ultra-high performance liquid chromatography (UHPLC)with reduced solvent consumption in the analysis was compared to the conventional HPLC method. A Fourier transform near-infrared (FT-NIR) spectroscopic method was applied based on the principal component scores for the prediction of extract/excipient mixtures and partial least squares regression model for quantitative analysis. NIR spectroscopy is an economic, powerful, and fast methodology for the detection of excipient in muirapuama dried extracts, generating no residue in the analysis. Scanning electron microscopy (SEM) images showed samples with a higher concentration of excipient, presenting better morphological characteristics and a lower moisture absorption rate. An eco-scale score value of 85 was achieved for UHPLC and 100 was achieved for NIR (excellent green analysis). Above all, these methods are rapid and green for the routine analysis of herbal medicines based on dried extracts. View Full-Text
Keywords: Ptychopetalum olacoides Benth; spray drying; green analytical techniques; UHPLC; NIR; SEM; dried extract; Analytical Eco-Scale; Muirapuama Ptychopetalum olacoides Benth; spray drying; green analytical techniques; UHPLC; NIR; SEM; dried extract; Analytical Eco-Scale; Muirapuama
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MDPI and ACS Style

Trindade, E.P.; Regis, F.T.; Araújo da Silva, G.; Nunes Aguillar, B.; de Paiva Amorim, M.V.; Ramos Ferreira, G.L.; Soares Aragão, C.F.; da Silva Solon, L.G. Laboratory-Scale Preparation and Characterization of Dried Extract of Muirapuama (Ptychopetalum olacoides Benth) by Green Analytical Techniques. Molecules 2020, 25, 1095.

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