Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model
Abstract
:1. Introduction
2. Results
2.1. Body Weight
2.2. Effects of LBPs on Echocardiographic Parameters
2.3. Effects of LBPs on Hematology Parameters
2.4. Effects of LBPs on Plasma Cytokines Levels
2.5. Effects of LBPs on Plasma Lipid Peroxidation
3. Discussion
4. Materials and Methods
4.1. Animals and Experimental Protocol
4.2. Echocardiography Measurements
4.3. Complete Blood Count
4.4. Proinflammatory Plasma Cytokines
4.5. Plasma Lipid Peroxidation
4.6. Data Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
Organ/BW Ratio (mg/g) | Control (n = 10) | AAB (n = 12) | AAB_100 (n = 7) | AAB_200 (n = 9) |
---|---|---|---|---|
Heart/BW | 1.59 ± 0.21 | 2.28 ± 0.33 * | 2.27 ± 0.18 * | 2.12 ± 0.18 * |
Lung/BW | 4.70 ± 0.24 | 5.03 ± 0.63 | 4.87 ± 0.47 | 4.75 ± 0.66 |
Kidney/BW | 1.96 ± 0.29 | 2.74 ± 0.41 * | 2.96 ± 0.42 * | 2.69 ± 0.35 * |
Liver/BW | 23.02 ± 1.90 | 23.57 ± 3.00 | 23.55 ± 3.86 | 23.44 ± 2.12 |
Hematology Parameters | Control (n = 10) | AAB (n = 12) | AAB_100 (n = 7) | AAB_200 (n = 9) |
---|---|---|---|---|
WBC | 9.01 ± 2.94 | 9.46 ± 1.55 | 9.10 ± 2.82 | 9.18 ± 2.65 |
LYM | 6.06 ± 1.62 | 6.50 ± 1.44 | 5.89 ± 1.63 | 6.57 ± 2.55 |
MID | 0.66 ± 0.52 | 0.61 ± 0.35 | 0.59 ± 0.35 | 0.44 ± 0.13 |
GRA | 2.29 ± 1.04 | 2.34 ± 0.72 | 2.63 ± 1.81 | 2.17 ± 0.81 |
LY | 69.16 ± 9.35 | 68.09 ± 8.29 | 66.67 ± 12.08 | 70.49 ± 8.72 |
MI | 6.56 ± 4.44 | 6.43 ± 3.21 | 5.89 ± 2.29 | 5.06 ± 2.10 |
GR | 24.27 ± 7.06 | 25.46 ± 8.59 | 27.49 ± 11.14 | 24.41 ± 8.74 |
RBC | 8.50 ± 0.63 | 8.62 ± 0.42 | 8.14 ± 0.57 | 8.14 ± 0.39 |
HGB | 14.74 ± 0.96 | 14.89 ± 0.52 | 14.70 ± 0.33 | 14.45 ± 0.27 |
HCT | 42.35 ± 2.37 | 42.80 ± 2.09 | 45.85 ± 4.07 | 45.18 ± 2.20 |
MCV | 50.11 ± 2.57 | 49.67 ± 1.57 | 56.29 ± 2.06 | 55.67 ± 1.73 |
MCH | 17.38 ± 0.89 | 17.54 ± 0.66 | 17.59 ± 0.54 | 17.13 ± 0.39 |
MCHC | 34.77 ± 0.50 | 35.33 ± 0.68 | 31.26 ± 0.83 | 30.83 ± 0.75 |
RDWc | 15.50 ± 0.74 | 16.61 ± 0.95 | 15.23 ± 1.05 | 15.52 ± 0.87 |
PLT | 672.60 ± 34.04 | 636.68 ± 195.5 | 673.75 ± 103.35 | 622.17 ± 103.34 |
PCT | 0.40 ± 0.23 | 0.49 ± 0.16 | 0.53 ± 0.27 | 0.37 ± 0.13 |
MPV | 6.86 ± 0.46 | 6.96 ± 0.30 | 7.24 ± 0.63 | 7.02 ± 0.34 |
PDWc | 33.76 ± 2.61 | 33.17 ± 0.93 | 33.70 ± 2.14 | 32.94 ± 0.87 |
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Pop, C.; Berce, C.; Ghibu, S.; Scurtu, I.; Sorițău, O.; Login, C.; Kiss, B.; Ștefan, M.G.; Fizeșan, I.; Silaghi, H.; et al. Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model. Molecules 2020, 25, 466. https://doi.org/10.3390/molecules25030466
Pop C, Berce C, Ghibu S, Scurtu I, Sorițău O, Login C, Kiss B, Ștefan MG, Fizeșan I, Silaghi H, et al. Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model. Molecules. 2020; 25(3):466. https://doi.org/10.3390/molecules25030466
Chicago/Turabian StylePop, Cristina, Cristian Berce, Steliana Ghibu, Iuliu Scurtu, Olga Sorițău, Cezar Login, Béla Kiss, Maria Georgia Ștefan, Ionel Fizeșan, Horațiu Silaghi, and et al. 2020. "Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model" Molecules 25, no. 3: 466. https://doi.org/10.3390/molecules25030466
APA StylePop, C., Berce, C., Ghibu, S., Scurtu, I., Sorițău, O., Login, C., Kiss, B., Ștefan, M. G., Fizeșan, I., Silaghi, H., Mocan, A., Crișan, G., Loghin, F., & Mogoșan, C. (2020). Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model. Molecules, 25(3), 466. https://doi.org/10.3390/molecules25030466