Next Article in Journal
How the Supramolecular Nature of Lignohumate Affects Its Diffusion in Agarose Hydrogel
Next Article in Special Issue
Human Nails Permeation of an Antifungal Candidate Hydroalcoholic Extract from the Plant Sapindus saponaria L. Rich in Saponins
Previous Article in Journal
Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix
Previous Article in Special Issue
Effects of Citicoline, Homotaurine, and Vitamin E on Contrast Sensitivity and Visual-Related Quality of Life in Patients with Primary Open-Angle Glaucoma: A Preliminary Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 25
Issue 24
10.3390/molecules25245832
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells

by
Chin-Feng Hsuan
1,2,†,
Yung-Chuan Lu
3,4,†,
I-Ting Tsai
1,5,
Jer-Yiing Houng
6,7,
Shih-Wei Wang
1,8,
Tzu-Hsien Chang
6,
Ya-Ling Chen
9 and
Chi-Chang Chang
3,9,*
1
School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
2
Division of Cardiology, Department of Internal Medicine, E-Da Hospital/E-Da Dachang Hospital, Kaohsiung 82445, Taiwan
3
School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan
4
Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
5
Department of Emergency, E-Da Hospital, Kaohsiung 82445, Taiwan
6
Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan
7
Department of Chemical Engineering, I-Shou University, Kaohsiung 84001, Taiwan
8
Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan
9
Department of Obstetrics & Gynecology, E-Da Hospital/E-Da Dachang Hospital, Kaohsiung 82445, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2020, 25(24), 5832; https://doi.org/10.3390/molecules25245832
Submission received: 7 November 2020 / Revised: 6 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Biological Activity of Plant Compounds and Extracts)
Browse Figures
Versions Notes

Abstract

The proliferation and migration of vascular smooth muscle cells (VSMCs) are essential in the pathogenesis of various vascular diseases, such as atherosclerosis and restenosis. Among the mediators of VSMC during atherosclerosis development, platelet-derived growth factor (PDGF)-BB is a potent mitogen for VSMCs and greatly contributes to the intimal accumulation of VSMCs. Glossogyne tenuifolia (GT, Xiang-Ru) is a traditional antipyretic and hepatoprotective herb from Penghu Island, Taiwan. This study evaluated the inhibitory effect of GT ethanol extract (GTE) and GT water extract (GTW) on proliferative and migratory activities in PDGF-BB-induced VSMCs. The experimental results demonstrated that GTE significantly inhibited the PDGF-BB-stimulated VSMC proliferation and migration, as shown by MTT, wound healing, and Boyden chamber assays. GTE was found to have a much more potent inhibitory activity than GTW. Based on the Western blot analysis, GTE significantly blocked the PDGF-BB-induced phosphorylation of NF-κB and mitogen-activated protein kinase (MAPK) pathways, including extracellular signal-regulated kinase (ERK), p38, and JNK, in VSMCs. In addition, GTE retarded the PDGF-BB-mediated migration through the suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression in VSMCs. Three main ingredients of GT—chlorogenic acid, luteolin-7-glucoside, and luteolin—all showed significant anti-proliferative effects on PDGF-BB-induced VSMCs. As a whole, our findings indicated that GTE has the potential to be a therapeutic agent to prevent or treat restenosis or atherosclerosis.
Keywords: Glossogyne tenuifolia; migration; platelet-derived growth factor; proliferation; vascular smooth muscle cell Glossogyne tenuifolia; migration; platelet-derived growth factor; proliferation; vascular smooth muscle cell

Share and Cite

MDPI and ACS Style

Hsuan, C.-F.; Lu, Y.-C.; Tsai, I.-T.; Houng, J.-Y.; Wang, S.-W.; Chang, T.-H.; Chen, Y.-L.; Chang, C.-C. Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells. Molecules 2020, 25, 5832. https://doi.org/10.3390/molecules25245832

AMA Style

Hsuan C-F, Lu Y-C, Tsai I-T, Houng J-Y, Wang S-W, Chang T-H, Chen Y-L, Chang C-C. Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells. Molecules. 2020; 25(24):5832. https://doi.org/10.3390/molecules25245832

Chicago/Turabian Style

Hsuan, Chin-Feng, Yung-Chuan Lu, I-Ting Tsai, Jer-Yiing Houng, Shih-Wei Wang, Tzu-Hsien Chang, Ya-Ling Chen, and Chi-Chang Chang. 2020. "Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells" Molecules 25, no. 24: 5832. https://doi.org/10.3390/molecules25245832

APA Style

Hsuan, C.-F., Lu, Y.-C., Tsai, I.-T., Houng, J.-Y., Wang, S.-W., Chang, T.-H., Chen, Y.-L., & Chang, C.-C. (2020). Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells. Molecules, 25(24), 5832. https://doi.org/10.3390/molecules25245832

Article Metrics

Back to TopTop