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“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine

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Laboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
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Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
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Department of Medical Sciences and Public Health, University of Cagliari, Policlinico Universitario, I-09042 Monserrato, Italy
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Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
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Authors to whom correspondence should be addressed.
Academic Editor: Antoine Loquet
Molecules 2020, 25(22), 5245; https://doi.org/10.3390/molecules25225245
Received: 18 September 2020 / Revised: 24 October 2020 / Accepted: 27 October 2020 / Published: 11 November 2020
(This article belongs to the Section Medicinal Chemistry)
Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions. View Full-Text
Keywords: amyloid; aggregation; metals; bioimaging; antiviral; cell penetrating peptides amyloid; aggregation; metals; bioimaging; antiviral; cell penetrating peptides
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MDPI and ACS Style

Abdelrahman, S.; Alghrably, M.; Lachowicz, J.I.; Emwas, A.-H.; Hauser, C.A.E.; Jaremko, M. “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules 2020, 25, 5245. https://doi.org/10.3390/molecules25225245

AMA Style

Abdelrahman S, Alghrably M, Lachowicz JI, Emwas A-H, Hauser CAE, Jaremko M. “What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine. Molecules. 2020; 25(22):5245. https://doi.org/10.3390/molecules25225245

Chicago/Turabian Style

Abdelrahman, Sherin, Mawadda Alghrably, Joanna I. Lachowicz, Abdul-Hamid Emwas, Charlotte A.E. Hauser, and Mariusz Jaremko. 2020. "“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine" Molecules 25, no. 22: 5245. https://doi.org/10.3390/molecules25225245

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