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Open AccessReview

Solubility and Bioavailability Enhancement of Oridonin: A Review

College of pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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Molecules 2020, 25(2), 332; https://doi.org/10.3390/molecules25020332
Received: 10 November 2019 / Revised: 7 January 2020 / Accepted: 9 January 2020 / Published: 14 January 2020
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI. View Full-Text
Keywords: Oridonin; structural modification; formulations; solubility; bioavailability; biological activity Oridonin; structural modification; formulations; solubility; bioavailability; biological activity
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MDPI and ACS Style

Zhang, Y.; Wang, S.; Dai, M.; Nai, J.; Zhu, L.; Sheng, H. Solubility and Bioavailability Enhancement of Oridonin: A Review. Molecules 2020, 25, 332.

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