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The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging

by Yanan Zhang 1,†, Xingwei Zhang 2,†, Yanping Shi 2, Chao Sun 2, Nan Zhou 2,* and Haixia Wen 1,*
1
Department of Physiology, Harbin Medical University, Harbin 150081, China
2
Department of Chemistry, Northeast Agricultural University, Harbin 150025, China
*
Authors to whom correspondence should be addressed.
The first two authors contributed equally to this work.
Molecules 2020, 25(2), 306; https://doi.org/10.3390/molecules25020306
Received: 20 November 2019 / Revised: 8 January 2020 / Accepted: 9 January 2020 / Published: 12 January 2020
The nitrogen-doped carbon dots (N-CQDs) were synthesized by citric acid as a raw material and propylene diamine as a passivation agent. Structure, optical properties and biocompatibility of N-CQDs were analyzed. It was found that the N-CQDs possessed concentration-dependent, multicolor photoluminescence and low toxicity. As demonstrated in the imaging of bioluminescence, by adjusting the concentration of N-CQDs, the cell imaging effect can be adjusted. The internalized N-CQDs were concentrated in the nucleus. A novel tool for studying the nuclear changes during the cell cycle was developed. View Full-Text
Keywords: nitrogen-doped carbon dots; multicolor illumination; multicolor cell nuclear imaging; mitosis nitrogen-doped carbon dots; multicolor illumination; multicolor cell nuclear imaging; mitosis
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MDPI and ACS Style

Zhang, Y.; Zhang, X.; Shi, Y.; Sun, C.; Zhou, N.; Wen, H. The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging. Molecules 2020, 25, 306.

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