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Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes

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Material Science Innovation and Modelling (MaSIM) Research Focus Area, Faculty of Natural and Agricultural Science, North-West University, Mafikeng Campus, Private Bag X2046, Mmabatho 2735, South Africa
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Department of Chemistry, Faculty of Natural and Agricultural Science, North-West University, Mafikeng Campus, Private Bag X2046, Mmabatho 2735, South Africa
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Author to whom correspondence should be addressed.
Academic Editor: Kristof Van Hecke
Molecules 2020, 25(2), 305; https://doi.org/10.3390/molecules25020305
Received: 14 December 2019 / Revised: 4 January 2020 / Accepted: 7 January 2020 / Published: 12 January 2020
(This article belongs to the Special Issue Metal Coordination Complexes for Biomedical Applications)
Interest in the synthesis of Bi(III) and Sb(III) dithiocarbamate complexes is on the rise, and this has been attributed to their wide structural diversity and their interesting application as biological agents and in solid state/materials chemistry. The readily available binding sites of the two sulphur atoms within the dithiocarbamate moiety in the complexes confers a wide variety of geometry and interactions that often leads to supramolecular assemblies. Although none of the bismuth or antimony metals are known to play any natural biological function, their dithiocarbamate complexes, however, have proven very useful as antibacterial, antileishmanial, anticancer, and antifungal agents. The dithiocarbamate ligands modulate the associated toxicity of the metals, especially antimony, since bismuth is known to be benign, allowing the metal ion to get to the targeted sites; hence, making it less available for side and other damaging reactions. This review presents a concise chemistry and some known biological potentials of their trivalent dithiocarbamate complexes. View Full-Text
Keywords: bismuth; antimony; dithiocarbamate; biological activities; structural properties bismuth; antimony; dithiocarbamate; biological activities; structural properties
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Adeyemi, J.O.; Onwudiwe, D.C. Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes. Molecules 2020, 25, 305.

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