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Open AccessReview

25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter

The Calcium Signalling Group, Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Academic Editors: Marie Migaud and Gerd Wagner
Molecules 2020, 25(18), 4220; https://doi.org/10.3390/molecules25184220
Received: 26 August 2020 / Revised: 8 September 2020 / Accepted: 14 September 2020 / Published: 15 September 2020
Ca2+-mobilizing adenine nucleotide second messengers cyclic adenosine diphosphoribose, (cADPR), nicotinic acid adenine dinucleotide phosphate (NAADP), adenosine diphosphoribose (ADPR), and 2′deoxy-ADPR were discovered since the late 1980s. They either release Ca2+ from endogenous Ca2+ stores, e.g., endoplasmic reticulum or acidic organelles, or evoke Ca2+ entry by directly activating a Ca2+ channel in the plasma membrane. For 25 years, Professor Barry Potter has been one of the major medicinal chemists in this topical area, designing and contributing numerous analogues to develop structure–activity relationships (SAR) as a basis for tool development in biochemistry and cell biology and for lead development in proof-of-concept studies in disease models. With this review, I wish to acknowledge our 25-year-long collaboration on Ca2+-mobilizing adenine nucleotide second messengers as a major part of Professor Potter’s scientific lifetime achievements on the occasion of his retirement in 2020. View Full-Text
Keywords: adenine nucleotide; second messenger; cADPR; NAADP; ADPR; 2′-deoxy-ADPR; Ca2+ signaling; T cell activation adenine nucleotide; second messenger; cADPR; NAADP; ADPR; 2′-deoxy-ADPR; Ca2+ signaling; T cell activation
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MDPI and ACS Style

Guse, A.H. 25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter. Molecules 2020, 25, 4220.

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