Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer
Abstract
1. Introduction
2. Cancer Immunotherapy
3. Tumor Immune Microenvironment (TIME)
4. Cancer Immunity Cycle
5. Clinical Evidence
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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ICIs | Target Molecules | Target Cancers |
---|---|---|
Ipilimumab | CTLA-4 | Colorectal cancer, HCC, Melanoma, NSCLC, RCC |
Pembrolizumab | PD-1 | Cervical cancer, Classic Hodgkin lymphoma, Cutaneous squamous cell carcinoma, Endometrial carcinoma, Gastric cancer, Gastroesophageal junction cancer, HCC, Melanoma, Merkel cell carcinoma, Microsatellite instability-high cancer, Mismatch repair deficient cancer, NSCLC, Primary mediastinal large B-cell lymphoma, RCC, SCLC, Solid tumors, Squamous cell carcinoma of the esophagus, Squamous cell carcinoma of the head and neck, Urothelial carcinoma |
Nivolumab | PD-1 | Classic Hodgkin lymphoma, Colorectal cancer, HCC, Melanoma, NSCLC, RCC, SCLC, Squamous cell carcinoma of the esophagus, Squamous cell carcinoma of the head and neck, Urothelial carcinoma |
Cemiplimab | PD-1 | Cutaneous squamous cell carcinoma |
Atezolizumab | PD-L1 | Breast cancer, HCC, NSCLC, SCLC, Urothelial carcinoma |
Durvalumab | PD-L1 | NSCLC, SCLC, Urothelial carcinoma |
Avelumab | PD-L1 | Merkel cell carcinoma, RCC, Urothelial carcinoma |
Trial | Cases | Disease | Regimen | RR (%) | PFS (months) | HR | OS (months) | HR |
---|---|---|---|---|---|---|---|---|
CheckMate 214 | 1096 | RCC | N/I continued vs. Sunitinib | 42 vs. 29 | 8.2 vs. 8.3 | 0.77 (0.65–0.90) p = 0.0014 | NR vs. 26.6 | 0.66 (0.54–0.80) p < 0.0001 |
IMmotion151 | 915 | RCC | A/B vs. Sunitinib | 43 vs. 37 | 11.2 vs. 7.7 | 0.74 (0.57–0.96) p = 0.0217 | 34.0 vs. 32.7 | 0.84 (0.62–1.15) p = 0.2857 |
JAVELIN Renal 101 trial | 886 | RCC | Avelumab/Axitinib vs. Sunitinib | 51.4 vs. 25.7 | 13.8 vs. 8.4 | 0.69 (0.56–0.84) p < 0.001 | Immature | Immature |
IMpower150 | 1191 | Non-Sq NSCLC | A/B/C/P or A/C/P vs. B/C/P | 56 vs. 4041 vs. 40 | 8.4 vs. 6.8 6.7 vs. 6.8 | 0.59 (0.50–0.69) 0.91 (0.78–1.06) | 19.8 vs. 14.9 19.5 vs. 14.9 | 0.76 (0.63–0.93) 0.85 (0.71–1.03) |
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Furukawa, K.; Nagano, T.; Tachihara, M.; Yamamoto, M.; Nishimura, Y. Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer. Molecules 2020, 25, 3900. https://doi.org/10.3390/molecules25173900
Furukawa K, Nagano T, Tachihara M, Yamamoto M, Nishimura Y. Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer. Molecules. 2020; 25(17):3900. https://doi.org/10.3390/molecules25173900
Chicago/Turabian StyleFurukawa, Koichi, Tatsuya Nagano, Motoko Tachihara, Masatsugu Yamamoto, and Yoshihiro Nishimura. 2020. "Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer" Molecules 25, no. 17: 3900. https://doi.org/10.3390/molecules25173900
APA StyleFurukawa, K., Nagano, T., Tachihara, M., Yamamoto, M., & Nishimura, Y. (2020). Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer. Molecules, 25(17), 3900. https://doi.org/10.3390/molecules25173900