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Article

High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina

by
Sher Ali
1,*,
Gul Badshah
1,
Caroline Da Ros Montes D’Oca
1,
Francinete Ramos Campos
2,
Noemi Nagata
1,
Ajmir Khan
3,4,
Maria de Fátima Costa Santos
1 and
Andersson Barison
1,*
1
NMR Lab, Department of Chemistry, Federal University of Paraná, Curitiba 81530-900, PR, Brazil
2
Department of Pharmacy, Federal University of Paraná, Curitiba 80210-170, PR, Brazil
3
School of Packaging, Michigan State University, East Lansing, MI 48824-1223, USA
4
Institute of Chemistry, University of São Paulo, São Paulo 05508-000, SP, Brazil
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(16), 3647; https://doi.org/10.3390/molecules25163647
Submission received: 11 April 2020 / Revised: 17 June 2020 / Accepted: 17 June 2020 / Published: 11 August 2020
(This article belongs to the Special Issue 25th Anniversary of Molecules—Recent Advances in Organic Synthesis)
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Abstract

Berberis laurina (Berberidaceae) is a well-known medicinal plant used in traditional medicine since ancient times; however, it is scarcely studied to a large-scale fingerprint. This work presents a broad-range fingerprints determination through high-resolution magical angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy, a well-established flexible analytical method and one of most powerful “omics” platforms. It had been intended to describe a large range of chemical compositions in all plant parts. Beyond that, HR-MAS NMR allowed the direct investigation of botanical material (leaves, stems, and roots) in their natural, unaltered states, preventing molecular changes. The study revealed 17 metabolites, including caffeic acid, and berberine, a remarkable alkaloid from the genus Berberis L. The metabolic pattern changes of the leaves in the course of time were found to be seasonally dependent, probably due to the variability of seasonal and environmental trends. This metabolites overview is of great importance in understanding plant (bio)chemistry and mediating plant survival and is influenceable by interacting environmental means. Moreover, the study will be helpful in medicinal purposes, health sciences, crop evaluations, and genetic and biotechnological research.
Keywords: Berberis laurina; metabolomic analysis; HR-MAS NMR; metabolites; chemometric analysis Berberis laurina; metabolomic analysis; HR-MAS NMR; metabolites; chemometric analysis
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MDPI and ACS Style

Ali, S.; Badshah, G.; Da Ros Montes D’Oca, C.; Ramos Campos, F.; Nagata, N.; Khan, A.; de Fátima Costa Santos, M.; Barison, A. High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina. Molecules 2020, 25, 3647. https://doi.org/10.3390/molecules25163647

AMA Style

Ali S, Badshah G, Da Ros Montes D’Oca C, Ramos Campos F, Nagata N, Khan A, de Fátima Costa Santos M, Barison A. High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina. Molecules. 2020; 25(16):3647. https://doi.org/10.3390/molecules25163647

Chicago/Turabian Style

Ali, Sher, Gul Badshah, Caroline Da Ros Montes D’Oca, Francinete Ramos Campos, Noemi Nagata, Ajmir Khan, Maria de Fátima Costa Santos, and Andersson Barison. 2020. "High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina" Molecules 25, no. 16: 3647. https://doi.org/10.3390/molecules25163647

APA Style

Ali, S., Badshah, G., Da Ros Montes D’Oca, C., Ramos Campos, F., Nagata, N., Khan, A., de Fátima Costa Santos, M., & Barison, A. (2020). High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina. Molecules, 25(16), 3647. https://doi.org/10.3390/molecules25163647

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